PedAM
Pediatric Disease Annotations & Medicines
| Disease | pancreatic cancer |
| Phenotype | C0011847|diabetes |
| Sentences | 59 |
| PubMedID- 22792091 | pancreatic cancer patients with diabetes were predominantly females, while diabetes was equally prevalent among sexes in the control group. |
| PubMedID- 24254337 | The us food and drug administration (fda) [35] and recent literature [36, 37] have highlighted controversies about the possible risks of pancreatitis and pancreatic cancer associated with some diabetes treatments. |
| PubMedID- 22960655 | Methods: using microarray analysis, we identified adrenomedullin as a potential mediator of diabetes in patients with pancreatic cancer. |
| PubMedID- 25576058 | Metformin treatment is associated with a decreased risk and better prognosis of pancreatic cancer (pc) in patients with type 2 diabetes, but the mechanism of metformin's pc growth inhibition in the context of a prediabetic state is unknown. |
| PubMedID- 25061491 | The occurrence of pancreatic cancer is associated with diabetes and impaired glucose metabolism. |
| PubMedID- 21416856 | [pancreatic cancer--association with diabetes mellitus and smoking]. |
| PubMedID- 25673969 | In the follow-up study, in which we assessed biomarkers in pancreatic cancer patients with diabetes after surgical resection, we found that the intensities of m/z at 1,465, 1,206, and 1,020 became comparable with those of diabetes-only patients. |
| PubMedID- 21416850 | [pancreatic cancer--association with diabetes mellitus and smoking]. |
| PubMedID- 24708788 | As shown in figure 5, the serum levels of mif in the following five group patients were examined: pancreatic cancer patients without diabetes, pancreatic patients with more than two years history of diabetes, pancreatic patients with less than two years history of diabetes (new-onset diabetes), healthy subjects with normal fasting glucose, and t2dm patients (without any other immune diseases or tumor) diagnosed within in two years. |
| PubMedID- 22520674 | Risk factors examined included: age, body mass index, smoking status, alcohol, deprivation, diabetes, pancreatitis, previous diagnosis of cancer apart from pancreatic cancer, dysphagia, abdominal pain, abdominal distension, appetite loss, weight loss, diarrhoea, constipation, tiredness, itching, and anaemia. |
| PubMedID- 24748867 | It is possible that new-onset diabetes associated with pancreatic cancer is due to a combination of beta cell dysfunction and an increased insulin resistance [1, 3]. |
| PubMedID- 23401773 | One hundred and twenty-six sera form pancreatic cancer patients (84 with diabetes) were examined by seldi-tof in comparison to 61 sera from chronic pancreatitis (32 with diabetes), 24 from type 2 diabetes mellitus patients, and 12 from healthy controls. |
| PubMedID- 22982797 | pancreatic cancer patients with coexisting diabetes had better overall survival than pancreatic cancer patients without diabetes (hazard ratio, 0.60; 95% confidence interval 0.44 to 0.80; p<0.001). |
| PubMedID- 25556126 | As pancreatic cancer induces diabetes in about 40% of patients,313233 we excluded retrospective and cross sectional studies to avoid reverse causality. |
| PubMedID- 21274445 | diabetes mellitus was associated with greater pancreatic cancer incidence [5, 6], although there is limited data supporting the theory that sugars or sweets are pathogenetically implicated [7]. |
| PubMedID- 25877316 | Objective: to investigate the changes of blood glucose in pancreatic cancer patients associated with diabetes mellitus (dm) after radiotherapy and analyze the related factors. |
| PubMedID- 25000673 | Information on the clinical profile of pancreatic cancer (pc) associated with diabetes mellitus (dm) is limited. |
| PubMedID- 22920886 | An additional study in americans analyzed a total of 1,172,496 case and control subjects and found that the frequency of pancreatic cancer in subjects with diabetes was 0.9% in comparison to subjects without diabetes (0.3%) [14]. |
| PubMedID- 26273663 | In literature, diabetes is associated with pancreatic cancer in 80% cases. |
| PubMedID- 24786605 | In this prospective cohort-based study, we observed that participants who reported having diabetes before being diagnosed with pancreatic cancer had worse survival compared with those who did not have diabetes. |
| PubMedID- 22517654 | Consistent with this possibility, epidemiological studies indicate that almost 1% of adults over age 50 with new-onset diabetes will be diagnosed with pancreatic cancer within 3 years (14). |
| PubMedID- 22015968 | Objectives: type 2 diabetes is associated with increased pancreatic cancer risk; however, the nature of this relationship is not clear. |
| PubMedID- 20601806 | Clinical outcome of pancreatic cancer patients with diabetes mellitus: is diabetes a poor prognostic factor. |
| PubMedID- 23667692 | Recently, epidemiologic data revealed that metformin, but not other antidiabetic drugs, decreases the incidence of pancreatic cancer in patients with diabetes mellitus [8], [9]. |
| PubMedID- 23669472 | Conclusions: diabetes is associated with pancreatic cancer risk and this is similar across different duration categories. |
| PubMedID- 24574842 | Several studies have found an increased incidence of pancreatic cancer in patients with diabetes mellitus (dm); however, other studies have shown that pancreatic cancer may cause glucose intolerance. |
| PubMedID- 22456038 | With long-standing type 2 diabetes, the risk of pancreatic cancer is increased by up to 50% (30,31). |
| PubMedID- 23053420 | This study examined whether gallstones, a cholecystectomy, chronic pancreatitis and the treatment of antidiabetic agents affect the risk of subsequent pancreatic cancer for patients with diabetes in a taiwanese population. |
| PubMedID- 23571023 | Studies have revealed that pancreatic cancer (pc) may lead to diabetes mellitus (dm). |
| PubMedID- 24224094 | Type 1 diabetes is associated with pancreatic cancer. |
| PubMedID- 25275365 | We observed greater magnitude of hazard ratios (hrs) of pancreatic cancer for patients with type 2 diabetes along with acute alcoholic hepatitis, acute pancreatitis, cholecystitis, and gastric ulcer compared with patients without type 2 diabetes or counterpart comorbidity (hr: 1.36, 95% confidence interval (ci): 1.19-1.56; 1.74, 1.23-2.45; 9.18, 7.44-11.33; and 2.31, 1.98-2.70, respectively). |
| PubMedID- 26439801 | Furthermore, the integrated optical density (iod) of sod2 and upa stainings is higher in the tumor tissues of pancreatic cancer patients with diabetes compared with pancreatic cancer patients with euglycemia. |
| PubMedID- 25856529 | In addition, diabetes may be associated with pancreatic cancer risk or it may be an early indicator of disease [15–17]. |
| PubMedID- 24136929 | Genetic factors that modify the associations of obesity and diabetes with pancreatic cancer have previously not been examined at the genome-wide level. |
| PubMedID- 26391180 | The limitations of the study are its retrospective design, the associated bias and the small number of samples in the study in pancreatic cancer patients with diabetes who underwent pancreatic cancer resection. |
| PubMedID- 21412116 | Recent-onset diabetes associated with pancreatic cancer likely represents secondary or type 3 diabetes. |
| PubMedID- 23835106 | The significant, positive association remained after excluding pancreatic cancer cases with recent-onset diabetes (or=1.92; 95%ci: 1.20–3.08). |
| PubMedID- 19844672 | A possible underlying mechanism to account for an increased risk of pancreatic cancer in people with obesity and/or diabetes is chronically increased pancreatic duct cell replication. |
| PubMedID- 26074965 | Similar survival benefits were seen in diabetes patients with pancreatic cancer on metformin [12]. |
| PubMedID- 24454807 | As bmi increased, mean age of the participants at baseline decreased, proportion of women increased, level of education displayed an inverse u-shaped curve, as did physical activity, diabetes was not associated with pancreatic cancer in the study, hr 1.384 (95% ci: 0.889–2.153). |
| PubMedID- 23393682 | Damaged pancreatic tissue, secondary to pancreatic cancer, leads to diabetes as islet cells and beta cells are taken over by malignancy. |
| PubMedID- 25641178 | In addition, the serum levels of opg were significantly higher in pancreatic cancer patients with new-onset diabetes than other groups including pancreatic patients without diabetes, new-onset type 2 diabetes and healthy controls. |
| PubMedID- 22750971 | New-onset diabetes with a history of dyslipidemia predicts pancreatic cancer. |
| PubMedID- 22084685 | diabetes mellitus is associated with pancreatic cancer in more than 80% of the cases. |
| PubMedID- 24837144 | Metformin is associated with reduced risk of pancreatic cancer in patients with type 2 diabetes mellitus: a systematic review and meta-analysis. |
| PubMedID- 22735942 | Risk factors and early signs of pancreatic cancer in diabetes: screening strategy based on diabetes onset age. |
| PubMedID- 23565475 | [24] association of diabetes with pancreatic cancer is controversial with some studies, suggesting a two-fold increase in patients of diabetes of >5 years duration and others suggesting diabetes to be protective against pancreatic cancer. |
| PubMedID- 24058443 | The risk factors considered were smoking, heavy alcohol intake, high bmi, diabetes, family history of pancreatic cancer, abo non-o blood group and three common genetic variants identified by gwas. |
| PubMedID- 25806358 | Reports also indicate the association of diabetes with pancreatic cancer [33] hence it is important to address the problem and to evaluate the relationship between them. |
| PubMedID- 23400555 | However, diabetes as a result of pancreatic cancer development is not infrequent, and chronic pancreatitis explains only less than 3% of pancreatic cancer cases. |
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