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PedAM

Pediatric Disease Annotations & Medicines




Disease overnutrition
Phenotype C0011860|type 2 diabetes
Sentences 2
PubMedID- 20689155 We were initially interested in determining whether p66shc may have a role in insulin resistance, the signaling dysfunction underlying glucose intolerance and type 2 diabetes associated with overnutrition and overweight.
PubMedID- 21709280 Because siblings discordant for intrauterine exposures carry a similar risk of inheriting the same susceptibility genes and share a similar postnatal environment, such studies provide strong evidence that the excess risk of childhood obesity and type 2 diabetes associated with fetal overnutrition reflects a specific intrauterine effect.

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