PedAM
Pediatric Disease Annotations & Medicines
| Disease | osteoarthritis |
| Phenotype | C0016053|fibromyalgia |
| Sentences | 3 |
| PubMedID- 22876216 | This review comprised the side-by-side analyses of 12 double-blind, placebo-controlled trials of duloxetine in patients with chronic pain (diabetic peripheral neuropathic pain, fibromyalgia, chronic pain due to osteoarthritis, and chronic low back pain). |
| PubMedID- 24379695 | Clbp is considered a mixed-pain syndrome, with the potential for multifactorial etiology and pain mechanisms, including nociceptive, neuropathic, and hyperalgesic components.35,36 duloxetine is believed to act upon descending inhibitory pain pathways,37 and has demonstrated efficacy in a variety of other chronic pain conditions, including dpnp,38,39 fibromyalgia,40,41 and pain associated with osteoarthritis of the knee.42 future studies, such as long-term pragmatic clinical trials or patient survey, physician survey, or chart review that collect data on effectiveness of treatment and reasons for treatment discontinuation or switch, are needed to confirm the drivers of treatment outcomes in clbp, including better compliance. |
| PubMedID- 20662040 | Adjusted for age and sex, the hazard ratio for fibromyalgia compared with osteoarthritis was 1.05 (95% ci 0.94-1.17). |
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