PedAM
Pediatric Disease Annotations & Medicines
| Disease | neutropenia |
| Phenotype | C0376545|hematologic malignancies |
| Sentences | 8 |
| PubMedID- 20509945 | Febrile neutropenia (fn) in patients with hematologic malignancies is characterized by increased susceptibility to sepsis complications, and a higher risk of septic shock, with mortality ranging from 2-21% [16]. |
| PubMedID- 23762675 | Major risk factors are prolonged, profound neutropenia in patients with hematologic malignancies and hsct recipients with t-cell deficiency on corticosteroids. |
| PubMedID- 25887489 | However, sxt is known to cause adverse events related to bone marrow suppression, which might delay recovery from neutropenia in patients with hematologic malignancies. |
| PubMedID- 22093149 | Trichosporon fungemia is a rare and fatal fungal infection that occurs in patients with prolonged neutropenia associated with hematologic malignancies. |
| PubMedID- 23990311 | Febrile neutropenia in hematologic malignancies. |
| PubMedID- 24596542 | Adverse events, which occurred in five patients (21.7%), were mild or moderate abnormal liver enzymes, that did not require discontinuation of the study drug, and all resolved after finishing micafungin.27 although the number of patients in this study was small, monotherapy with micafungin for febrile neutropenia in patients with hematologic malignancies appeared to be safe and efficacious. |
| PubMedID- 24319213 | Evidence-based approach to treatment of febrile neutropenia in hematologic malignancies. |
| PubMedID- 22058202 | Conclusions: based on the high negative predictive value of this diagnostic and therapeutic approach in persistent febrile neutropenia patients with hematologic malignancies or patients who have received a hematopoietic stem cell transplant, the approach is useful for identifying patients who are not likely to develop invasive fungal infection and do not, therefore, require antifungal therapy. |
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