PedAM
Pediatric Disease Annotations & Medicines
| Disease | neutropenia |
| Phenotype | C0040034|thrombocytopenia |
| Sentences | 14 |
| PubMedID- 21116412 | Dose limiting toxicities according to the manufacturer’s spc: anc < 500/μl for more than five days or neutropenia associated with fever/infection; thrombocytopenia < 25.000/μl; bilirubin > uln; ap > 2.5× uln; ast/alt > 2.5× uln. |
| PubMedID- 26229484 | This increased proliferation leads to cytopenias, which commonly present with neutropenia leading to infections, thrombocytopenia leading to bleeding complications, and anemia presenting as dyspnea on exertion or at rest.1 the incidence of aml increases with age, with the median age of diagnosis being 65–70 years.2 the cytopenias and the elderly age at presentation complicate the treatment with standard induction, showing very poor survival at 2 years.2 even for patients of younger age (<60 years), the standard-of-care treatments have not changed significantly for the better in the past. |
| PubMedID- 21610706 | Dose-limiting toxicities consisted exclusively of myelosuppression (neutropenia with or without thrombocytopenia), leading to a delay in initiation of cycle 2 dosing. |
| PubMedID- 21949519 | Thus, vsga or sga infants are particularly vulnerable to bleeding with thrombocytopenia or infection associated with neutropenia especially early after birth. |
| PubMedID- 20178634 | Wiskott-aldrich syndrome is an x-linked disorder characterized by current infection, thrombocytopenia (with small platelets), neutropenia, eczema, high ige levels, a very high prevalence of autoimmunity (including arthropathy, vasculitis, and inflammatory bowel disease) and malignancy. |
| PubMedID- 26332545 | Treatment-related adverse events included grade 4 thrombocytopenia (in 18% of patients), grade 4 neutropenia (in 12%), grade 3 anemia (in 30%), and grade 1 or 2 elevation in levels of total bilirubin (in 12%), alkaline phosphatase (in 21%), and aspartate aminotransferase (in 27%). |
| PubMedID- 21899744 | A leukaemic picture is invariably found, associated with prominent thrombocytopenia and variable degrees of anaemia and neutropenia [165]. |
| PubMedID- 24489398 | Adverse events included thrombocytopenia in 41% of dogs, neutropenia in 17% of dogs, and gastrointestinal toxicity in 13% of dogs. |
| PubMedID- 23807894 | Initially, the patient presented only with neonatal refractory thrombocytopenia until 3 years of age, post-infected neutropenia, and late presentation of eczema, but his disease progressed rapidly with a a life-threatening event of intracranial hemorrhage. |
| PubMedID- 24299473 | Evans syndrome (es) is a rare hematological disease commonly defined by the combination of simultaneous or sequential autoimmune hemolytic anemia (aiha) and immune thrombocytopenia (itp) sometimes associated with neutropenia in the absence of known underlying etiology. |
| PubMedID- 23401442 | The major toxicity was transient grades 3 to 4 thrombocytopenia (87% of patients); febrile neutropenia occurred in 12%. |
| PubMedID- 20960521 | Grade 3/4 (according to national cancer institute common toxicity criteria [version 3.0]) thrombocytopenia occurred in 47% of patients, neutropenia in 63%, and anemia in 37% of patients. |
| PubMedID- 21455428 | [9–11] typically, the platelet count falls to 80% of the normal and thrombocytopenia may be associated with neutropenia and anemia. |
| PubMedID- 21845438 | Grade 3/4 thrombocytopenia occurred in 28% of patients, neutropenia in 34%. |
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