PedAM
Pediatric Disease Annotations & Medicines
| Disease | neutropenia |
| Phenotype | C0003864|arthritis |
| Sentences | 4 |
| PubMedID- 24659095 | Felty's syndrome is a rare variant of severe seropositive rheumatoid arthritis with neutropenia and splenomegaly. |
| PubMedID- 24634201 | Late-onset neutropenia in patients with rheumatoid arthritis after treatment with rituximab. |
| PubMedID- 25819216 | Most cases of neutropenia in patients with rheumatoid arthritis (ra) are acquired. |
| PubMedID- 24350896 | The frequencies of mutations in asian cases of t-lgl l and clpd-nk were rather high compared with those in reports on western cohorts,5,6 although mutations in addition to these two were also detected in previously reported studies.5,6 several clinical differences have been suggested between asian and western lgl l populations.7,9 in asian populations, prca is the most common hematological complication of t-lgl l and clpd-nk, in contrast to the situation in western countries where rheumatoid arthritis and infections due to neutropenia are more frequent in cases of lgl l.1,17 in a subset of bone marrow failure syndrome such as mds and aa, stat3-mutated t-cell subclones were found, suggesting contributions of stat3-mutated t cells to immune dysregulation in these disorders.18 significant associations of stat3 sh2 domain mutations and prca in the present study further imply their roles in prca, another type of immune-mediated cytopenia. |
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