PedAM
Pediatric Disease Annotations & Medicines
| Disease | neural tube defects |
| Phenotype | C0016412|folic acid deficiency |
| Sentences | 1 |
| PubMedID- 22837425 | It could be argued that the antifolate activity of metformin, although largely restricted to tumor cells requiring higher nucleotide concentrations, may also affect rapidly dividing cells, such as those within the bone marrow, and promote neural tube defects associated with folic acid deficiency (e.g., spina bifida and anencephaly). |
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