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PedAM

Pediatric Disease Annotations & Medicines




Disease nephrotic syndrome
Phenotype C0033687|proteinuria
Sentences 54
PubMedID- 21151138 Therefore, treatment with sialic acid precursors constitute a potential therapeutic tool to reduce proteinuria in some forms of nephrotic syndrome.
PubMedID- 26511325 Furthermore, a systemic hyperosmolar state from proteinuria and hypoalbuminemia associated with nephrotic syndrome contributes to the leakage of fluid into the suprachoroidal space [6].
PubMedID- 22461531 Results: initially, 95% of patients had nephrotic syndrome with proteinuria of 3-12 g per 24 hours, creatinine levels of 0.6-9.6 mg/dl, positive lupus serologies, and normal complement levels in 63%.
PubMedID- 24527245 These cytokine and inflammatory mediators are thought to damage the glomerular foot processes, leading to proteinuria and other sequelae of nephrotic syndrome [8].
PubMedID- 23295293 Nephropathy in fs consists in nephrotic syndrome (ns) with proteinuria that begins early in childhood and progressively increases with age, mainly due to nonspecific focal and segmental glomerular sclerosis (fsgs).
PubMedID- PMC4044283 Subsequently, the patient developed proteinuria with nephrotic syndrome.
PubMedID- 23006339 In september 2010, her nephrotic syndrome returned with proteinuria (9.5 g/d), anasarca (11.3 kg weight gain), hyperlipidemia (total cholesterol 332 mg/dl, ldl 229 mg/dl, triglycerides 270 mg/dl), and a cr of 1.9 mg/dl.
PubMedID- 21534236 Clinically, lg is characterized by proteinuria generally associated with nephrotic syndrome and progressive renal insufficiency.
PubMedID- 24294005 At the time of biopsy, six (75%) of them had nephrotic syndrome with mean proteinuria of 3.8 ± 2.24 g/day.
PubMedID- 22909024 They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients.
PubMedID- 22661128 Because of a lack of ultrastructural detail (the electron microscopy was not invented until 50 years later) and limited by only a superficial insight in renal inflammatory processes, the authors failed to recognize the glomerulus as the origin of proteinuria in patients with the nephrotic syndrome and placed too much emphasis on tubular reabsorption patterns coined lipoid nephrosis.
PubMedID- 21502717 Renal amyloidosis is typically characterized by nephrotic syndrome, often with massive proteinuria and refractory peripheral edema.
PubMedID- 23670304 Podocyte loss correlated with lower selectivity of proteinuria in patients with minimal change nephrotic syndrome and focal segmental glomerulosclerosis (r = -0.90; p < 0.001).
PubMedID- 26395882 In the first year of life, 66 % of the patients suffering from hypoalbuminemia and severe proteinuria are diagnosed with genetic nephrotic syndrome (gns) [1].
PubMedID- 24282415 Due to persistent activation of the chronic inflammatory process, whether clinically manifested orsubclinically, excess saa is deposited in the form of fibrils in various organs, particularly the kidneys, with the consequent progressive development of severe proteinuria, leading to nephrotic syndrome and kidney failure.
PubMedID- 20419132 Mutations of the nephrin gene lead to congenital nephrotic syndrome with proteinuria and renal failure [12].
PubMedID- 19773419 Recurrence of nephrotic-range proteinuria in patients with idiopathic nephrotic syndrome (ins) and focal and segmental glomerulosclerosis (fsgs) on native kidneys is associated with poor graft survival.
PubMedID- 23559294 Background: collapsing glomerulopathy is a cause of nephrotic syndrome with massive proteinuria secondary to podocyte proliferation and glomerular collapse.
PubMedID- 23479095 Presenting features comprise any of the following: proteinuria (sometimes with the nephrotic syndrome), haematuria, hypertension and renal failure.
PubMedID- 26054711 Serum half-life of rtx can be extremely short, partly due to excessive urinary losses in therapy-resistant nephrotic syndrome with non-selective proteinuria, as seen in our patient.
PubMedID- 23569546 Gemcitabine treatment may be associated with proteinuria to the extent of nephrotic syndrome.
PubMedID- 22078716 Hypo-albuminemia accompanied by significant proteinuria is a component of the nephrotic syndrome that may accompany active lupus renal disease.
PubMedID- 25688242 Lupus nephritis is a frequent and potentially serious complication among patient with systemic lupus erythematosus whose clinical manifestations are varied being the most common manifestations proteinuria (commonly leading to nephrotic syndrome), microscopic hematuria, and reduced gfr.
PubMedID- 23476687 Mutations in the podocin gene cause severe structural podocyte alterations and massive proteinuria leading to nephrotic syndrome [25].
PubMedID- 23162265 The limited evidence suggested that dfz appeared to be equally effective in inducing remission or decreasing proteinuria in patients with nephrotic syndrome.
PubMedID- 21403411 Although a moderate degree of proteinuria is common in patients with igan, nephrotic syndrome is considered uncommon in these patients.3 the course of igan is variable, and 15% to 40% of patients progress to end-stage renal disease over a period of 10 to 20 years.4 the pathogenesis of igan is complex and not completely understood.
PubMedID- 23275781 In february 2011, the patient was referred to the department of nephrology for the appearance of edema, increase of the serum creatinine up to 1.5 mg/dl (egfr 45.0 ml/min/1.73 m2), weight gain (weight was 67.5 kg), nephrotic syndrome with proteinuria of 12 g/24 h, dyslipidemia, and hypoalbuminemia.
PubMedID- 24886259 Mutations in the podocin gene cause severe structural podocyte alterations and massive proteinuria leading to nephrotic syndrome [22].
PubMedID- 24404368 During the follow-up period on allopurinole and anti-proteinuirc treatment, the patient had normal renal function with mild to moderate proteinuria and no recurrence of nephrotic syndrome.
PubMedID- 24611049 In the systemic loop, it binds to glomerular endothelial αvβ5 integrin and reduces proteinuria, the principal driver of nephrotic syndrome.
PubMedID- 26551740 Focal segmental glomerulosclerosis (fsgs) is a pathologic entity that is a common cause of nephrotic syndrome with severe proteinuria in both adults and children.
PubMedID- 25874088 Here we report an association between collapsing glomerulopathy and an acute ebv syndrome, manifesting itself clinically as nephrotic syndrome with massive proteinuria, hypoalbuminemia, anasarca and hypercholesterolemia.
PubMedID- 23759297 Results: all patients presented with proteinuria, associated with nephrotic syndrome (41%), hematuria (73%), and hypertension (70%).
PubMedID- 24749114 A year after the beginning of the symptoms she sought medical attention: a diagnosis of nephrotic syndrome with proteinuria >10 g/l was made.
PubMedID- 23878704 They further described a glomerulopathy, which was characterised by heavy proteinuria, biochemical features of nephrotic syndrome, renal impairment that rapidly progressed to end stage renal disease (rao et al., 1984).
PubMedID- 21132650 A 47-year-old woman was referred to our unit for evaluation of proteinuria associated with nephrotic syndrome.
PubMedID- 23782479 Haematuria and proteinuria and subsequent development of nephrotic syndrome and chronic kidney disease (ckd) represent the commonest manifestations of hiv-related glomerular disease (table 1) [13].
PubMedID- 25886386 Studies also showed that as-iv can attenuate podocyte injury and ameliorate proteinuria in adults with idiopathic nephrotic syndrome [16].
PubMedID- 22534961 In 129x1/svj mice, proteinuria, chemical indices of nephrotic syndrome and glomerular and tubulointerstitial accumulation of type-i collagen and fibronectin occur sequentially after adr administration.
PubMedID- 20483511 Diagnostic strategy relies on the clinical presentation: acute renal failure, chronic kidney disease, glomerular proteinuria with or without nephrotic syndrome, tubular proteinuria, hydroelectrolytic disorders.
PubMedID- 23197960 In conclusion, bilateral rae is an alternative, effective, rapid, and safe procedure for the treatment of heavy proteinuria with nephrotic syndrome.
PubMedID- 23434736 The proband presented at 3 weeks of age with generalised oedema and was found to have severe hypoalbuminaemia and proteinuria and was diagnosed with congenital nephrotic syndrome.
PubMedID- 24317117 Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome.
PubMedID- 21497573 Renal manifestations are frequent, mostly characterized by heavy proteinuria, with nephrotic syndrome and renal failure in more than half of the patients at diagnosis.
PubMedID- 26447100 Background: proteinuria leading to nephrotic syndrome is a rare adverse event arising from treatment with bevacizumab.
PubMedID- 24860853 Although sirolimus is not generally thought to be nephrotoxic, it can be associated with proteinuria, which can lead to nephrotic syndrome and subsequent kidney injury (25).
PubMedID- 21335185 Post-olt 3 patients developed proteinuria, 2 of whom showed increasing nephrotic syndrome.
PubMedID- 26203254 Renal toxicity is an uncommon ae of all nsaids, and risk is elevated in those who have preexisting severe hepatic or renal dysfunction, nephrotic syndrome with high-level proteinuria, older age, diabetes, hypertension, congestive heart failure, or dehydration.
PubMedID- 24798567 Rituximab, a chimeric monoclonal antibody against the cd20 antigen on b cells, safely reduced proteinuria in patients with nephrotic syndrome secondary to membranous nephropathy, minimal change disease, or focal segmental glomerulosclerosis.
PubMedID- 21904677 The development of nephrotic-range proteinuria, without full nephrotic syndrome, is consistent with the role of b4 as a minor podocyte integrin.

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