PedAM

Pediatric Disease Annotations & Medicines

Disease	n syndrome
Phenotype	C0497327\|dementia
Sentences	23
PubMedID- 23601808	Evidence that picalm affects age at onset of alzheimer's dementia in down syndrome.
PubMedID- 22888254	Down syndrome patients with dementia also show loss of memory, cognitive decline, changes in adaptive behavior, neurological changes, and language difficulties;25,26 these symptoms are progressive (not reversible).27 in contrast, the clinical features of individuals with acute neuropsychiatric disorders appear to be more similar to those of individuals with psychiatric illnesses, such as major depressive and obsessive-compulsive disorder or schizophrenia (table 1).
PubMedID- 25735452	Down syndrome (ds) patients with early-onset dementia share similar neurodegenerative features with alzheimer's disease (ad).
PubMedID- 25363568	The presentation of dementia in down syndrome differs compared with typical alzheimer's disease.
PubMedID- 23400708	Apoe4 is a major genetic risk factor for alzheimer disease and is associated with dementia in down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders.
PubMedID- 21542885	The clinical and scientific study of dementia in adults with down syndrome led to the development of the amyloid hypothesis as a fundamental concept in alzheimer's disease pathogenesis.
PubMedID- 25594074	The purpose of this mini review is to provide an updated assessment on apolipoprotein e4 status and risk potential of developing dementia and mortality associated with down syndrome.
PubMedID- 25720405	Our findings suggest the potential value of this gene as a blood marker of early dementia in individuals with down syndrome.
PubMedID- 22763204	Seronegative sneddon syndrome, complicated with dementia, was diagnosed in each case by noticing an association between, on mri, an atrophy and several ischemic cerebrovascular accident aftermaths, and a livedo racemosa.
PubMedID- 24406638	Recent research has tended to focus on dementia in down syndrome.
PubMedID- 26483832	Cognitive rehabilitation of dementia in adults with down syndrome: a review of non-pharmacological interventions.
PubMedID- 21041786	Change in plasma ass peptides and onset of dementia in adults with down syndrome.
PubMedID- 26343344	Behavioural and psychological symptoms of dementia in down syndrome: early indicators of clinical alzheimer's disease.
PubMedID- 26275564	In our study, we aimed to screen patients affected by atypical parkinsonian syndromes or pd complicated by psychosis or dementia for the presence of c9orf72 repeat expansions, and in unrelated age- and sex-matched healthy controls.
PubMedID- 19760624	The commonest diagnoses were depression (20.2%), anxiety (5.6%), hypochondriasis (4.4%), and organic brain syndrome with or without dementia (3.6%).
PubMedID- 20597723	Improvements in understanding the progression of dementia in individuals with down syndrome may lead to improved diagnosis and treatment.
PubMedID- 21739598	We conclude that antioxidant supplementation is safe, though ineffective as a treatment for dementia in individuals with down syndrome and alzheimer type dementia.
PubMedID- 23902161	Conclusion: the previously reported high risk levels for dementia among people with down syndrome was confirmed in these data as was the value of the instruments utilised in tracking decline and helping to confirm diagnosis even in persons with severe intellectual disability.
PubMedID- 23662834	Purpose: to investigate the frequency of alzheimer-related dementia in patients with pseudoexfoliation syndrome (pex).
PubMedID- 20367747	Background: the latter stages of dementia in individuals with down syndrome are well documented; however, earlier cognitive and behavioural changes have only recently been described.
PubMedID- 24885175	Interestingly, down syndrome patients with ad dementia also have an increase in mtdna mutations[9].
PubMedID- 25551263	Variability of the aging process in dementia-free adults with down syndrome.
PubMedID- 26288825	These findings suggest a protective role of mtrnr2l12 in the development of early alzheimer's disease-like dementia in adults with down syndrome.

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