PedAM
Pediatric Disease Annotations & Medicines
| Disease | n syndrome |
| Phenotype | C0023448|lymphoblastic leukemia |
| Sentences | 7 |
| PubMedID- 24391118 | Outcome of transplantation for acute lymphoblastic leukemia in children with down syndrome. |
| PubMedID- 24222333 | Acute lymphoblastic leukemia in children with down syndrome: a retrospective analysis from the ponte di legno study group. |
| PubMedID- 24072241 | Acute lymphoblastic leukemia developing in a patient with noonan syndrome harboring a ptpn11 germline mutation. |
| PubMedID- 22072402 | High frequency of btg1 deletions in acute lymphoblastic leukemia in children with down syndrome. |
| PubMedID- 20418240 | Results: overall, 468 courses of methotrexate (1-5 g/m(2)) were given to 44 acute lymphoblastic leukemia patients with down syndrome and to 87 acute lymphoblastic leukemia patients without down syndrome. |
| PubMedID- 21926964 | Additional activated forms of jak2 include oncogenic fusions, such as pcm1-jak2 as a consequence of a recurrent t(8;9)(p21;p24) or point mutations at sites different from v617, such as the r683g mutation in down syndrome children with b-progenitor acute lymphoblastic leukemias (b-all), additional jak2 point mutations in pediatric or adult b-all and others 29-32. further, oncogenic cytokine receptors, including crlf2 in b-all can lead to constitutive jak2 signaling 32. there may be substantial overlap in jak2 signaling and analogous mutations in the jak2 kinase domain would be predicted to cause drug resistance similar to the results observed in our study. |
| PubMedID- 20806366 | T-cell acute lymphoblastic leukemia in association with borjeson-forssman-lehmann syndrome due to a mutation in phf6. |
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