PedAM
Pediatric Disease Annotations & Medicines
| Disease | myocardial infarction |
| Phenotype | C0032461|polycythemia |
| Sentences | 2 |
| PubMedID- 24044106 | In a meta-analysis of 19 rcts including 1,084 subjects, t-treated subjects were nearly 4 times as likely as those in the placebo arm to develop a hematocrit >50%.44 similar results were reported by another meta-analysis.45 erythrocytosis has been reported to occur in healthy older men mainly after parenteral and oral t administration, but usually not after transdermal t.1,2,6 some reports indicate the occurrence of myocardial infarction or stroke associated with t-induced polycythemia, resulting from intermittent high-dose t administration.1,2,6 hence, it is important to monitor the hematocrit at regular intervals, to avoid potentially serious adverse events.1,2,6 in addition, pre-existing erythrocytosis constitutes a risk factor for thrombosis in hypogonadal men.1,2,6 guidelines indicate that a hematocrit >54% is an indication to stop trt until the hematocrit decreases to a safe level.6,10,12 phlebotomy can also be considered in the most severe cases. |
| PubMedID- 24438641 | Acute st-elevation myocardial infarction in a patient with polycythemia vera. |
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