PedAM
Pediatric Disease Annotations & Medicines
| Disease | multiple endocrine neoplasia |
| Phenotype | C0027662|multiple endocrine neoplasia |
| Sentences | 70 |
| PubMedID- 26161274 | multiple endocrine neoplasia type 1 is an autosomal dominant disorder characterized by the presence of endocrine tumors in several organs, including parathyroid, gastroenteropancreatic tract, and pituitary [5]. |
| PubMedID- 23730622 | multiple endocrine neoplasia type 2 (men2, omim 171400), associated with pheos, medullary thyroid carcinoma, and other manifestations, is linked to gain-of-function mutations in the ret gene (mulligan et al., 1993; hofstra et al., 1994). |
| PubMedID- 21826256 | For patients with a family history of mtc or multiple endocrine neoplasia 2a or 2b, prophylactic thyroidectomy is recommended as soon as possible, even in patients who are less than one-year-old [6]. |
| PubMedID- 23756599 | We have recently identified a multiple endocrine neoplasia syndrome occurring in a sprague–dawley-derived rat strain (named menx) characterized by the occurrence of spontaneous pas with complete penetrance. |
| PubMedID- 24832650 | Mutations responsible for a number of familial cancer syndromes (beckwith-wiedemann syndrome, li-fraumeni syndrome, multiple endocrine neoplasia type 1) have also been shown to present as somatic mutations in sporadic acc. |
| PubMedID- 24959251 | multiple endocrine neoplasia type 1 (men1) is an autosomal dominant cancer predisposition syndrome (1), caused by mutations in the men1 gene (2). |
| PubMedID- 22145140 | Genetic analysis for familial syndromes like ret protooncogene for multiple endocrine neoplasia type 2 (men 2), vhl mutation for vhl(von hippel lindeau) and succinate dehydrogenase (sdh) mutations need to be looked for in all children with pheochromocytoma. |
| PubMedID- 22584708 | The cosegregation of hirschsprung's disease and multiple endocrine neoplasia 2 is particularly interesting as it involves both “switch off” and “switch on” of the rearranged during transfection proto-oncogene in the same patient. |
| PubMedID- 20862373 | This is different from the multiple endocrine neoplasia syndromes in which the primary tumorigenic gene mutations are inherited. |
| PubMedID- 24213229 | Abbreviations: men-1 = multiple endocrine neoplasia type 1 with signs of pancreatic tumor; nf pnet = non-functioning pancreatic net; acth-prod pnet = acth producing pancreatic net giving rise to ectopic cushing’s syndrome; si-net = small intestinal net; caput = pancreatic head; corp = pancreatic body; cauda = pancreatic tail; liver × 10 = approximately 10 metastases in the liver; lgll = pathological lymph nodes; mes lgll = mesenteric metastatic lymph nodes; gastr = gastric tumor; adre = adrenal gland tumor; int = intestinal tumor; duod = duodenum; tp = true positive; tn = true negative; fp = false positive; fn = false negative. |
| PubMedID- 25628771 | multiple endocrine neoplasia type 2 (men2) is an autosomal dominant inherited endocrine malignancy syndrome, with an occurrence of approximately 1 in 30 000; men2 is due to germline mutations in the rearranged during transfection (ret) proto-oncogene (omim: 164761) [1,2], which includes the following three subtypes: men2a (omim: 171400); familial medullary thyroid cancer (fmtc; omim: 155240); and men2b (omim: 162300) [3]. |
| PubMedID- 23418495 | Patients with genetically confirmed multiple endocrine neoplasia type 1 (men-1 syndrom) or type 2a (men-2a syndrome) based on verified mutations in the meni gene or ret gene, respectively, were excluded. |
| PubMedID- 22584709 | multiple endocrine neoplasia type 2 (men2) is an autosomal-dominant hereditary cancer syndrome caused by missense mutations in the ret (rearranged during transfection) proto-oncogene, and these result in the gain-of-function of the encoding receptor tyrosine kinase (1). |
| PubMedID- 21843357 | multiple endocrine neoplasia type 2a (men2a) or sipple syndrome is an autosomal dominant syndrome, first described by sipple [1] and later characterized in multiple kindreds by schimke [2], caused by misense mutations in the ret protooncogene [3,4], a tyrosine kinase receptor. |
| PubMedID- 21540209 | For example, the multiple endocrine neoplasia type 2 (men 2), an inherited cancer syndrome characterized by medullary thyroid carcinoma (mtc) and pheochromocytoma (pc), was caused by germline mutations in the exon region, encoding one of three specific cysteine residues in the extracellular domain of the ret protein. |
| PubMedID- 22359510 | multiple endocrine neoplasia (men) type 2 is characterized by thyroid cancer, variable penetrance of tumors or hyperplasia in other endocrine organs and mutations in ret, the receptor tyrosine kinase proto-oncogene “rearranged during transfection” [1], [2]. |
| PubMedID- 23754889 | A 23-year-old female patient with no family history of multiple endocrine neoplasia (men) syndrome, familial mtc, or sporadic mtc was diagnosed with spontaneous metastatic mtc in march, 1993. |
| PubMedID- 23236420 | multiple endocrine neoplasia type 2 (men2) is composed of three clinical subtypes, multiple endocrine neoplasia type 2a (men2a), familial medullary thyroid carcinoma, and multiple endocrine neoplasia type 2b, all of which are associated with germline mutations in the ret proto-oncogene. |
| PubMedID- 23869313 | multiple endocrine neoplasia-1 (men1) is an autosomal dominant syndrome described for the first time in 1954 by moldawers and colleagues and wermer separately. |
| PubMedID- 25191209 | multiple endocrine neoplasia type 2a (men 2a) or sipple's syndrome, is a hereditary familial syndrome consisting of pheocromocytoma (pheo) in 50% of cases, medullary thyroid carcinoma (mtc) in 90-100% and primary hyperparathyroidism (phpt) in 20-30%. |
| PubMedID- 20842232 | multiple endocrine neoplasia 1 is a syndrome resulting from mutation in the men1 gene located in the chromosomal region 11q13. |
| PubMedID- 22615588 | Men1, classified as a gate keeper tumor suppressor gene is responsible for multiple endocrine neoplasia type1 (2) and is widely observed in non-endocrine as well as endocrine and exocrine tissues (3, 4). |
| PubMedID- 21897551 | There was no evidence of associated multiple endocrine neoplasia, which is known to occur in about 4% of patients. |
| PubMedID- 20063095 | multiple endocrine neoplasia type 2 (men 2) syndrome is a rare autosomal inherited complex of endocrine tumors caused by a mutation in the rearranged during transfection (ret) proto-oncogene located on chromosome 10. |
| PubMedID- 22185228 | Ophthalmological and oral manifestations of multiple endocrine neoplasia 2b, as in the case of our patient, are rare presentations of the disease; unfortunately in the case of our patient his condition had not been noted and acted upon until he presented to our department. |
| PubMedID- 21369528 | multiple endocrine neoplasia (men1) is characterized by the presence of tumours related to two or more endocrine glands in the same patient. |
| PubMedID- 23417499 | Ept can also be part of type i multiple endocrine neoplasia (men-i) syndrome, in which multiple pancreatic tumours are almost always found. |
| PubMedID- 24353437 | Hypercalcemia may also be part of a hereditary syndrome (multiple endocrine neoplasia [men1] or multiple endocrine neoplasia type 2a [men2a]) particularly when identified in children or young adults.2,3 parathyroid lesions are routinely identified with 99 mtc-sestamibi scintigraphy scans and often successfully treated with surgical resection. |
| PubMedID- 22992277 | multiple endocrine neoplasia type 2 (men 2) is an autosomal dominant hereditary cancer syndrome with a prevalence of about 1 in 30,000 [1]. |
| PubMedID- 23093970 | multiple endocrine neoplasia type 2 (men2) is a rare familial syndrome caused by mutations in the ret protooncogene. |
| PubMedID- 24379037 | However, contrarily to recommendations for other syndromes with thyroid cancer predisposition such as multiple endocrine neoplasia syndromes, thyroidectomy is not employed in brrs patients without nodules (18). |
| PubMedID- 26444007 | Mucosal neuromas are highly associated with multiple endocrine neoplasia type 2b (men-2b), which occurs in patients with germline mutation of ret genes [11]. |
| PubMedID- 26229531 | Patients with the multiple endocrine neoplasia type 1 (men1) syndrome carry a heterozygous germline inactivating mutation in men1 that predisposes to tumors of multiple endocrine and nonendocrine tissues (omim id 131100 and 613733) [1–3]. |
| PubMedID- 24531709 | One of such examples is the cancer syndrome multiple endocrine neoplasia type 1 (men1) 1, 2. individuals with germline mutations of the men1 gene are predisposed to develop hyperplasia and tumors in the endocrine pancreas, anterior pituitary and parathyroid. |
| PubMedID- 24281099 | multiple endocrine neoplasia type 2a (men 2a) was assigned to chromosome 10 by linkage analysis in 1987, when the location of the ret gene was still unknown [52]. |
| PubMedID- 25545711 | The multiple endocrine neoplasia type 1 syndrome (men1) is a rare autosomal dominant hereditary cancer syndrome characterized by the development of endocrine tumors in different sites. |
| PubMedID- 22584707 | We will briefly review hirschsprung disease (hscr), multiple endocrine neoplasia type 2 (men2), and the co-segregation of these conditions in the few families that have been studied to date. |
| PubMedID- 22761894 | multiple endocrine neoplasia type 1 (men1) syndrome is a rare complex tumor-predisposing disorder inherited in an autosomal dominant manner [12]. |
| PubMedID- 24826336 | As a result, once a diagnosis of pheochromocytoma is made, it is important to rule out any evidence of hereditary syndromes like multiple endocrine neoplasia type 2, neurofibromatosis type 1, and von hippel-landau syndrome in the patient. |
| PubMedID- 23170141 | For example, patients with multiple endocrine neoplasia (men) typically have p-nets in 36% to 81% of patients. |
| PubMedID- 20351961 | A 32-year-old saudi male patient who is a known case of multiple endocrine neoplasia type 1 (men1) status post parathyroidectomy, distal panreatectomy and spleenectomy in 2006 was found, on ct screening, to have extra luminal midesophageal mass about five cm in greatest dimension at the level of the carina, compatible with leiomyoma [figure 1]. |
| PubMedID- 26343727 | multiple endocrine neoplasia type 1 (men-1 syndrome), a hereditary condition associated with tumors of the endocrine (hormone producing) glands, and the tumor suppressor gene men1 is frequently mutated in this disease. |
| PubMedID- 22584710 | multiple endocrine neoplasia type 2 has been a model in clinical cancer genetics, demonstrating how knowledge of the genetic basis can shape the diagnosis and treatment of the disease. |
| PubMedID- 22007213 | Five patients with a family history of multiple endocrine neoplasia (men) were excluded, giving a total of 45 patients evaluated in the present study. |
| PubMedID- 24499519 | It has similarities with mccune-albright syndrome, multiple endocrine neoplasia and certain kinds of hamartomas, especially peutz-jeghers in terms of the mucosal lentigines[6]. |
| PubMedID- 23776892 | To screen high risk patients for thyroid malignancy like patients with history of familial thyroid cancer, multiple endocrine neoplasia (men) type ii and irradiated neck in childhood. |
| PubMedID- 23304085 | Ten to 15% of all pnets are part of familial syndromes such as multiple endocrine neoplasia type 1, von hippel-lindau, neurofibromatosis and tuberous sclerosis [3], which will not be reviewed further in this paper. |
| PubMedID- 24251161 | Pht was accompanied with multiple endocrine neoplasia-1 in one patient and pregnancy in another case. |
| PubMedID- 22844555 | multiple endocrine neoplasia (men) is an autosomal dominant inherited disease presenting with tumorous lesions, mainly in various endocrine organs. |
| PubMedID- 22087368 | Most adrenal tumors are sporadic and unilateral, but 2% to 6% of adrenal tumors are bilateral and associated with li-fraumeni syndrome, type i multiple endocrine neoplasia, beckwith-wiedemann syndrome, and carney complex, principally in children [1-4]. |
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