PedAM
Pediatric Disease Annotations & Medicines
| Disease | multiple endocrine neoplasia |
| Phenotype | C0025267|multiple endocrine neoplasia type 1 |
| Sentences | 21 |
| PubMedID- 23418495 | Patients with genetically confirmed multiple endocrine neoplasia type 1 (men-1 syndrom) or type 2a (men-2a syndrome) based on verified mutations in the meni gene or ret gene, respectively, were excluded. |
| PubMedID- 24959251 | multiple endocrine neoplasia type 1 (men1) is an autosomal dominant cancer predisposition syndrome (1), caused by mutations in the men1 gene (2). |
| PubMedID- 23304085 | Ten to 15% of all pnets are part of familial syndromes such as multiple endocrine neoplasia type 1, von hippel-lindau, neurofibromatosis and tuberous sclerosis [3], which will not be reviewed further in this paper. |
| PubMedID- 26343727 | multiple endocrine neoplasia type 1 (men-1 syndrome), a hereditary condition associated with tumors of the endocrine (hormone producing) glands, and the tumor suppressor gene men1 is frequently mutated in this disease. |
| PubMedID- 26229531 | Patients with the multiple endocrine neoplasia type 1 (men1) syndrome carry a heterozygous germline inactivating mutation in men1 that predisposes to tumors of multiple endocrine and nonendocrine tissues (omim id 131100 and 613733) [1–3]. |
| PubMedID- 21124979 | The multiple endocrine neoplasia type 1 tumor suppressor gene (men1) has been implicated in the control of apoptosis, dna repair or replication, and gene expression [1]. |
| PubMedID- 22837571 | Bhds should be considered, along with tuberous sclerosis and multiple endocrine neoplasia type 1 in the differential diagnosis of multiple facial angiofibromas and collagenomas, particulary when the onset is in adulthood. |
| PubMedID- 26161274 | multiple endocrine neoplasia type 1 is an autosomal dominant disorder characterized by the presence of endocrine tumors in several organs, including parathyroid, gastroenteropancreatic tract, and pituitary [5]. |
| PubMedID- 23760585 | Furthermore, mutations of the trxg component multiple endocrine neoplasia type 1 (men1) are found in neuroendocrine pancreatic tumors and is mutually exclusive with daxx and atrx mutations, suggesting similar functional roles (jiao et al., 2011). |
| PubMedID- 26191410 | multiple endocrine neoplasia type 1 (men-1) is a rare autosomal-dominant disease characterized by the combined manifestations of tumors in the pancreas, parathyroid and pituitary glands. |
| PubMedID- 25827640 | A lymnaea homologue of the multiple endocrine neoplasia type 1 (men1) tumor suppressor gene that encodes for the transcription factor menin was previously shown to be required in the postsynaptic neuron for proper synapse formation35. |
| PubMedID- 24658317 | Concurrently, 4 patients with pnets had multiple endocrine neoplasia type 1 and 2 patients had von hippel-lindau disease in association with familial syndromes. |
| PubMedID- 22754549 | multiple endocrine neoplasia type 1 (men1) is an autosomal dominant familial endocrine neoplasm syndrome characterized by tumors in parathyroids, enteropancreatic endocrine tissues, and the anterior pituitary. |
| PubMedID- 23569534 | multiple endocrine neoplasia type 1 (men1), also called wermer syndrome, is an autosomal-dominant disorder caused by a mutation in the menin gene on chromosome 11q13 [1]. |
| PubMedID- 24832650 | Mutations responsible for a number of familial cancer syndromes (beckwith-wiedemann syndrome, li-fraumeni syndrome, multiple endocrine neoplasia type 1) have also been shown to present as somatic mutations in sporadic acc. |
| PubMedID- 25545711 | The multiple endocrine neoplasia type 1 syndrome (men1) is a rare autosomal dominant hereditary cancer syndrome characterized by the development of endocrine tumors in different sites. |
| PubMedID- 24213229 | Abbreviations: men-1 = multiple endocrine neoplasia type 1 with signs of pancreatic tumor; nf pnet = non-functioning pancreatic net; acth-prod pnet = acth producing pancreatic net giving rise to ectopic cushing’s syndrome; si-net = small intestinal net; caput = pancreatic head; corp = pancreatic body; cauda = pancreatic tail; liver × 10 = approximately 10 metastases in the liver; lgll = pathological lymph nodes; mes lgll = mesenteric metastatic lymph nodes; gastr = gastric tumor; adre = adrenal gland tumor; int = intestinal tumor; duod = duodenum; tp = true positive; tn = true negative; fp = false positive; fn = false negative. |
| PubMedID- 24531709 | One of such examples is the cancer syndrome multiple endocrine neoplasia type 1 (men1) 1, 2. individuals with germline mutations of the men1 gene are predisposed to develop hyperplasia and tumors in the endocrine pancreas, anterior pituitary and parathyroid. |
| PubMedID- 20351961 | A 32-year-old saudi male patient who is a known case of multiple endocrine neoplasia type 1 (men1) status post parathyroidectomy, distal panreatectomy and spleenectomy in 2006 was found, on ct screening, to have extra luminal midesophageal mass about five cm in greatest dimension at the level of the carina, compatible with leiomyoma [figure 1]. |
| PubMedID- 22319650 | They can occur as part of multiple endocrine neoplasia type 1 (men type i) syndrome, or more often they occur in isolation. |
| PubMedID- 22761894 | multiple endocrine neoplasia type 1 (men1) syndrome is a rare complex tumor-predisposing disorder inherited in an autosomal dominant manner [12]. |
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