PedAM
Pediatric Disease Annotations & Medicines
| Disease | mental depression |
| Phenotype | C0598639|hypercortisolemia |
| Sentences | 4 |
| PubMedID- 23955525 | Measurement of salivary, urinary, or serum cortisol levels reveal that depression is associated with hypercortisolemia in older depressed subjects [15–20]. |
| PubMedID- 22211368 | Conclusion: classical feed-forward overdrive and impaired feedback theories of hypercortisolemia in depression were not supported. |
| PubMedID- 22848407 | Similar to the bone loss observed in cushing syndrome as a result of hypercortisolemia, women with depression could thus have decreased bmd, albeit not as pronounced as in cushing syndrome. |
| PubMedID- 24302944 | Previous studies have reported that stress during early life can cause alterations in hpa axis functioning later in life.20,21 findings from animal studies suggest that early-life stress can produce persistent epigenetic changes that lead to hyperactivity of the hpa axis in adulthood, which in turn increases susceptibility to mood disorders.22,23 interestingly, hpa axis hyperactivity in depression has been associated with hypercortisolemia and reduced inhibitory feedback. |
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