PedAM

Pediatric Disease Annotations & Medicines

Disease	mental depression
Phenotype	C0002766\|analgesia
Sentences	19
PubMedID- 24567812	It provides excellent sedation and analgesia with minimal respiratory depression [2,3,5].
PubMedID- 24665253	Our aim was to utilize the gastrostomy as enteral route to provide sedation and analgesia with neither respiratory depression nor airway obstruction during the procedure.
PubMedID- 20814550	The anesthetic challenges during dbs include providing sedation and analgesia with minimal respiratory depression or interference with electrophysiologic brain mapping and clinical testing.
PubMedID- 26137757	Use of opioids to provide adequate perioperative analgesia often leads to respiratory depression, nausea, vomiting, urinary retention, pruritus, and opioid-induced hyperalgesia, with the potential to increase length of stay in the hospital.
PubMedID- 25886334	Background: regional anesthesia, increasingly used for infraumbilical surgery, has advantages of decreased stress response to surgery, nausea, vomiting, and cardio-respiratory depression with improved postoperative analgesia, in comparison to general anesthesia.
PubMedID- 26543645	Recent evidence shows that dexmedetomidine, an α2 agonist, can provide excellent sedation (anxiolysis, sedation, and analgesia without the risk of respiratory depression) during awake fiberoptic intubation in the management of difficult airway and also to patients in critical care units [15–19].
PubMedID- 23166445	The ceiling analgesic dose, which is defined as a dose that produces the greatest analgesic effect with tolerable side effects, was used to assess morphine efficacy.29 in a meta-analysis, 21 clinical studies measured analgesia and side effects of it morphine (respiratory depression).
PubMedID- 22241946	A reduced need for repeat doses of opioid analgesia, which is associated with neonatal respiratory depression, is also a substantial benefit of a shorter labor process.
PubMedID- 22923826	Background: opioid analgesics used for analgesia are associated with sedation, respiratory depression and post-operative nausea and vomiting.
PubMedID- 26283834	Background: use of opioids for perioperative analgesia is associated with sedation, respiratory depression and postoperative nausea and vomiting.
PubMedID- 25191180	[12] any post-operative side-effects, for example nausea, vomiting, itching, bradycardia, hypotension, excessive sedation, inadequate analgesia, retention of urine or respiratory depression defined as respiratory rate <10/min or spo2 <90%, were recorded.
PubMedID- 23403854	Dexmedetomidine (dex), a highly selective α2-receptor agonist, provides excellent sedation and analgesia with minimal respiratory depression (14).
PubMedID- 25222672	Conclusion: gal021 produces respiratory stimulatory effects during opioid-induced respiratory depression with containment of opioid-analgesia and without any further increase of sedation.
PubMedID- 24833636	depression scores correlated with weaker placebo analgesia, whereas state and trait anxiety were not associated.
PubMedID- 25816912	Novel kappa-opioid receptor agonist mb-1c-oh produces potent analgesia with less depression and sedation.
PubMedID- 25313880	Background: there is an unmet clinical need to develop a pharmacological therapy to counter opioid-induced respiratory depression without interfering with analgesia or behavior.
PubMedID- 24709876	Disruption of the mor gene leads to a complete loss of the main biological actions of morphine, including analgesia, reward, withdrawal, respiratory depression, immunosuppression and constipation, demonstrating that both therapeutic and adverse effects of the prototypic opioid results from its interaction with mor gene products [35,36,37,38,39,40,41,42].
PubMedID- 22220219	It provides excellent sedation and analgesia with minimal respiratory depression [1].
PubMedID- 21235376	Conclusions and clinical relevance: tramadol administered po at 5 to 10 mg/kg provided thermal analgesia with less respiratory depression than that reported for morphine in red-eared slider turtles.

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