PedAM
Pediatric Disease Annotations & Medicines
| Disease | mental depression |
| Phenotype | C0001622|hypercortisolism |
| Sentences | 7 |
| PubMedID- 25290346 | As psychiatric disorders like depression are associated with hypercortisolism, leptin is proposed to exert anti-depressant-like effects due to its inhibition of chronically overactive hypothalamo-pituitary-adrenal axis function. |
| PubMedID- 23904409 | Conclusion: our data confirmed that treatment-resistant depression is associated with hypercortisolism and these patients no longer show an hypothalamic-pituitary-adrenal response to the administration of a mineralocorticoid receptor antagonist, suggesting that there is a mineralocorticoid receptor malfunctioning, such as a down regulation, however, pharmacokinetics and pharmacodynamics in these subjects could also have had an effect on the lack of mineralocorticoid receptor response. |
| PubMedID- 26103454 | Sometimes, however, qol may not normalize completely, especially if it is caused by a craniopharyngioma (because of concomitant neuropsychological comorbidities that affect autonomy and cognitive function), or functional pituitary tumours, i.e., in cushing's disease, in which chronic brain exposure to hypercortisolism is associated with more depression, anxiety, loss of memory and emotional distress. |
| PubMedID- 23869268 | Whereas hypercortisolism is associated with clinical depression, this observation has also been made in the nonclinical range of depression in healthy young men [82]. |
| PubMedID- 24932586 | Conclusions: relative hypocortisolism and relative hypercortisolism were associated with depression and lower life quality, providing novel insights into the detrimental role of stress in bipolar disorder. |
| PubMedID- 22220285 | An alternative explanation is that the blunted tsh response may be induced by the hypercortisolism associated with depression or the elevated thyroid hormone levels mediated by adrenergic mechanisms [60, 61]. |
| PubMedID- 24109426 | It is important to note that hypercortisolism is often associated with melancholic depression, a subtype of clinical depression that is accompanied by anhedonia, hypophagia and weight loss; while atypical depression, the most common form of depression, is characterized by reduced hpa activity, improved mood in response to positive events and increased appetite, carbohydrate craving and frequently weight gain (juruena and cleare, 2007). |
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