PedAM
Pediatric Disease Annotations & Medicines
| Disease | malaria |
| Phenotype | C0039730|thalassemia |
| Sentences | 5 |
| PubMedID- 23853772 | The protection of α+-thalassemia against malaria might be due to higher susceptibility of homozygotes to malaria in early life that immunize these individuals and make them resistance to malaria later [7]. |
| PubMedID- 25915902 | In a conclusion, a high frequency of alleles such as g6pd deficiency, hbs, hbc and α-thalassemia associated with malaria resistance were present on bioko island. |
| PubMedID- 24478401 | We found a significant interaction between hp genotype and alpha(+)thalassemia in predicting risk of severe malaria: hp2-1 in combination with heterozygous or homozygous alpha(+)thalassemia was associated with protection from severe malaria (or, 0.73; 95% ci, 0.54-0.99 and or, 0.48; 95% ci, 0.32-0.73, respectively), but alpha(+)thalassemia in combination with hp2-2 was not protective. |
| PubMedID- 22623996 | One study associated α-thalassemia with reduced risk of severe plasmodium falciparum malaria in papua new guinea [1], but only recently have epidemiological studies confirmed this finding in sub-saharan africa. |
| PubMedID- 26174819 | Interestingly, it is of note for the coexistence of malaria with only α-thalassemia-2 but not α-thalassemia-1, the commonly found thalassemia type in southeast asia. |
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