PedAM

Pediatric Disease Annotations & Medicines

Disease	malaria
Phenotype	C0024534\|cerebral malaria
Sentences	11
PubMedID- 25858094	As a consequence, it was held that most malaria deaths were attributable to cerebral malaria and, thus, were primarily neurological in origin, with a smaller number resulting from severe malarial anaemia, which could be mitigated by an immediate blood transfusion.
PubMedID- 21707906	Severe malaria, including cerebral malaria (cm), is characterized by the sequestration of parasitized erythrocytes in the microvessels after cytoadherence to endothelial cells.
PubMedID- 23226502	The discovery cohort comprised of 367 malaria-positive children with either cerebral malaria (cm), severe malarial anemia (sma) or uncomplicated malaria (um), and 289 malaria-negative children who were either disease controls (dc) or community controls (cc) (table 1).
PubMedID- 21923924	Comparisons are made between severe malaria patients with cerebral malaria (cm) and those that died from other severe complications of malarial disease (non-cm).
PubMedID- 22110393	In holoendemic transmission areas, sma is the primary clinical manifestation of severe childhood malaria, with cerebral malaria occurring only in rare cases.
PubMedID- 21172048	The plasmodium converts arginine to ornithine and causes depletion in the host cell which is related to the human malarial hypoargininemia associated with cerebral malaria pathogenesis[18].
PubMedID- 22253622	Immune profiles were compared between malaria patients with (cerebral malaria) and without (including uncomplicated disease, asymptomatic plasmodium falciparum carriers) neurological symptoms.
PubMedID- 25495520	However, they are inflammatory and alter the permeability of the blood-brain barrier, raising concerns that their use as a treatment for malaria could lead to cerebral malaria (cm), a severe complication of the disease.
PubMedID- 25879828	Seventy five percent of complicated malaria cases were associated with cerebral malaria, 30% with acute kidney injury, 45% with hyperparasitaemia, 35% with schizontaemia and 35% with severe anaemia.
PubMedID- 26445879	The sample collection was carried out from february 2005 to may 2007 and comprised 288 severe malaria children (130 with cerebral malaria and 158 with severe malaria but not cerebral malaria), 142 patients with uncomplicated malaria and 319 uninfected controls.
PubMedID- 20931035	The manifestations of severe malaria include: cerebral malaria, severe anemia, hemoglobinuria, pulmonary edema or ards, abnormalities in blood coagulation and thrombocytopenia, cardiovascular collapse and shock, acute kidney failure, hyperparasitemia, metabolic acidosis and hypoglycemia.

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