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PedAM

Pediatric Disease Annotations & Medicines




Disease malabsorption syndrome
Phenotype C0030293|pancreatic insufficiency
Sentences 11
PubMedID- 19804466 Background: pancreatic enzyme supplements are standard therapy for fat malabsorption in patients with exocrine pancreatic insufficiency.
PubMedID- 25742431 Objective: in shwachman-diamond syndrome (sds), pancreatic insufficiency can lead to malabsorption of fat-soluble vitamins and trace elements.
PubMedID- 22416231 Eating was also adversely affected highlighting the other major pathological effect of cf which is on the gastrointestinal system, where 95% of patients show exocrine pancreatic insufficiency with symptoms of malabsorption and constipation (mason, 2005).
PubMedID- 26102351 Progressive lung disease, pancreatic insufficiency leading to fat malabsorption and fat soluble vitamin deficiencies, cf-related diabetes, bone disease, and male infertility are common cf presentations.
PubMedID- 22110412 Approximately 85% of patients with cf have pancreatic insufficiency (pi) leading to maldigestion and malabsorption (4, 5).
PubMedID- 21659619 Maldigestion due to exocrine pancreatic insufficiency leads to intestinal malabsorption and consequent malnutrition, a mechanism proposed to cause growth retardation associated with cystic fibrosis (cf).
PubMedID- 20958263 Yarrowia lipolytica lipase has been assumed to be a good candidate for the treatment of fat malabsorption in patients with pancreatic insufficiency.
PubMedID- 23201848 However, it also exhibits pancreatic insufficiency that leads to malabsorption of dietary lipids.
PubMedID- 21932505 The consequence of this abnormal protein is thick, viscous secretions in the lungs and gi tract, which lead to recurrent lung infections and pancreatic insufficiency with intestinal malabsorption.
PubMedID- 20127304 Involvement of the gastrointestinal tract generally manifests as exo- and later endocrine pancreatic insufficiency with diabetes mellitus, malabsorption and sometimes biliary liver cirrhosis.
PubMedID- 25389061 Malnutrition could result from a discrepancy between energy needs and food intake while malabsorption results from pancreatic insufficiency which occurs in 85% of people with cf.

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