PedAM

Pediatric Disease Annotations & Medicines

Disease	malabsorption syndrome
Phenotype	C0017152\|gastritis
Sentences	6
PubMedID- 22254022	Tests that diagnose atrophic gastritis, a common cause of vitamin b12 malabsorption, include gastroscopy or serum gastrin and pepsinogen levels.
PubMedID- 20607069	Risk factors for vitamin b12 deficiency include low animal protein intake, malabsorption associated with atrophic gastritis or helicobacter pylori infection, pancreatic or intestinal pathology, and gastric acid-reducing medications [6,30-32].
PubMedID- 21436999	Risk factors for vitamin b12 deficiency include low animal protein intake, malabsorption associated with atrophic gastritis (which increases with age), or helicobacter pylori infection, pancreatic or intestinal pathology, and gastric acid-reducing medications [13–16].
PubMedID- 23618390	Diagnosis of gord was based on self-report as were gastrointestinal diseases which include peptic ulcer, chronic gastritis and causes of malabsorption, such as pancreatitis, gastric surgery, chronic diarrhoea, irritable bowel syndrome, inflammatory bowel syndrome and coeliac disease.
PubMedID- 20505848	Although pa and scd share the common etiology, type a (autoimmune) chronic atrophic gastritis, with vitamin b12 malabsorption, they have distinct pathophysiologies.18,201 in the methionine cycle, folate- and vitamin b12-dependent ms catalyzes hcy methylation to met, as ch3-thf, serving as the methyl group donor, is demethylated to thf.47,52,58,151,200 impairment of this reaction causes defective dna synthesis, leading to megaloblastic, macrocytic anemia (ie, pa).21,58 supplemental folic acid can override the impairment, restoring dna synthesis and normalizing erythropoiesis.58,401 furthermore, in the methionine cycle, met is adenosylated to sam, which is demethylated to sah, which is deadenosylated to hcy.58 impairment of sam demethylation to sah impedes methylation reactions, leading to vacuolar demyelination, axonal degeneration, and neuronal death (ie, scd).21,58 supplemental folic acid cannot override the methylation impairment, resulting in progressive neuropathology and neuronal death.58 treating a combined folate and b12 deficiency with folic acid alone may correct hematological abnormalities, but not neurological abnormalities, and can aggressively worsen b12-deficient neurological sequelae.7,18,19,23,200,203,355 thus, b12 deficiency should be ruled out before correcting folate deficiency.
PubMedID- 22546014	H. pylori can cause b12 malabsorption by hypochlorhydria associated with atrophic gastritis which may lead to a failure in the splitting of b12 from food binders and its subsequent transfer to salivary r-binder in the stomach [6].

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