PedAM
Pediatric Disease Annotations & Medicines
| Disease | lymphopenia |
| Phenotype | C0025202|melanoma |
| Sentences | 1 |
| PubMedID- 24790790 | In humans, the congenital absence of the il-7 receptor results in a severe combined immunodeficiency syndrome characterized by the loss of t lymphocytes but normal production of nk cells and b lymphocytes.31,32 il-7 levels typically increase in response to declining amounts of t lymphocytes, such as observed in hiv-infected patients, in cancer patients responding to lymphodepleting chemotherapy, or upon the administration of t cell-specific antibodies.33,34 for example, in melanoma patients with chemotherapy-induced lymphopenia prior to bone marrow transplant, circulating il-7 levels rise to a median of about 30 pg/ml.16 the exogenous administration of il-7 can increase circulating cd4+ and cd8+ lymphocyte counts, demonstrating a clear role for il-7 in this immunoregulatory process. |
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