PedAM
Pediatric Disease Annotations & Medicines
| Disease | lupus |
| Phenotype | C0027697|nephritis |
| Sentences | 51 |
| PubMedID- 20415236 | We report a case of biopsy-proven lupus vasculopathy, with lupus nephritis class iv-g (a). |
| PubMedID- 23056926 | The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. |
| PubMedID- 25637896 | Association between the presence of anti-c1q antibodies and active nephritis in patients with systemic lupus erythematosus. |
| PubMedID- 25883715 | A unifying working diagnosis of systemic lupus erythematosus (sle) with lupus nephritis was made. |
| PubMedID- 23566295 | For lupus, including nephritis, we are still some distance from achieving thesame level of understanding and standardisation in the clinical trial setting. |
| PubMedID- 21542875 | This reduction could provisionally explain why the chromatin concentration in circulation of lupus patients with nephritis is reported to be higher than in control individuals [77,78]. |
| PubMedID- 24204176 | Systemic lupus erythematosus with active lupus nephritis was suspected. |
| PubMedID- 21245596 | While renal biopsy is the gold standard for diagnosis and assessment of nephritis in patients with lupus, it is an invasive procedure that cannot be performed serially for monitoring purposes. |
| PubMedID- 23947749 | [27] diagnosed systemic lupus erythematosus with lupus nephritis and severe hypertension in a 23-year-old man. |
| PubMedID- 22006377 | Objective: autoantibody immune complexes and cellular infiltrates drive nephritis in patients with systemic lupus erythematosus (sle) and in murine lupus. |
| PubMedID- 20423534 | These double negative il-17-producing t cells were shown to infiltrate kidneys of lupus patients with nephritis [56]. |
| PubMedID- 20334681 | In our study, lupus patients with nephritis had a trend toward an increased frequency of cd4+il-17+ t cells and cd3+cd4-il-17+ t cells compared with those without nephritis. |
| PubMedID- 23251783 | Furthermore, the up-regulation of the inflammasome-activating dna sensor absent in melanoma 2 (aim2) in a mouse model of lupus and in patients with sle-associated nephritis (roberts et al., 2009; kimkong et al., 2009) and the presence of anti-dna-pk and anti-rna-pol iii antibodies in patients with sle and systemic sclerosis (cavazzana et al., 2008, 2009) makes the link between dna sensing and autoimmune disorders worthy of further investigation. |
| PubMedID- 25926050 | Background/aims: there is a critical need for more noninvasive biomarkers to identify nephritis in patients with systemic lupus erythematosus (sle). |
| PubMedID- 22171659 | Mutations in genes encoding complement inhibitors cd46 and cfh affect the age at nephritis onset in patients with systemic lupus erythematosus. |
| PubMedID- 25889583 | Neubert and colleagues [26] showed that reduced nephritis in mice with lupus-like disease was attributed to btz-induced plasma cell reduction. |
| PubMedID- 22923758 | Attenuation of nephritis in lupus-prone mice by thalidomide. |
| PubMedID- 22044622 | A systematic, microarray-based investigation of microrna expression in epstein-barr virus-transformed b cell lines of lupus patients with nephritis and controls in caucasian and african-american populations observed reproducible overexpression of a number of micrornas across ethnicities [73]. |
| PubMedID- 23866287 | [a case report of systemic lupus erythematosus complicated by lupus nephritis following histiocytic necrotizing lymphadenitis]. |
| PubMedID- 23553192 | Conclusion: treatment with srage significantly improved nephritis in lupus-prone mice, with efficacy comparable to that of standard induction treatment for lupus nephritis. |
| PubMedID- 24382281 | In univariate analysis, the risk factors that associated with severe np manifestations included more organ damage, cutaneous vasculitis, nephritis flare, the presence of antiphospholipid antibodies, particularly lupus anticoagulant and anti-cardiolipin immunoglobulin g (igg acl), abnormal mri of the brain and aggressive use of immunosuppressives. |
| PubMedID- 22886616 | Dexamethasone prodrug treatment prevents nephritis in lupus-prone (nzb x nzw)f1 mice without causing systemic side effects. |
| PubMedID- 21309006 | Methods: sixty-eight systemic lupus erythematosus patients with lupus nephritis were enrolled. |
| PubMedID- 25012167 | We tested the hypothesis that amplified expression of csf-1 detected in the serum or urine correlates with intrarenal csf-1 expression and histopathology (increased macrophage accumulation, activity indices) and clinical kidney disease activity and predicts the onset and recurrence of nephritis in patients with systemic lupus erythematosus (sle). |
| PubMedID- 21876349 | Conclusion: in lupus subjects with active nephritis, bindarit significantly reduced albuminuria and urinary ccl2 levels. |
| PubMedID- 23970121 | Comparing cases of systemic lupus erythematosus with nephritis and healthy controls revealed a stronger association at rs7708392 in european americans but not at rs4958881 in african americans. |
| PubMedID- 26062902 | (2010) observed that il-23r deficiency prevented the development of nephritis in lupus-prone mice. |
| PubMedID- 26558120 | Pauci-immune necrotizing and crescentic glomerulonephritis with membranous lupus nephritis, fifteen years after initial diagnosis of secondary membranous nephropathy. |
| PubMedID- 22529611 | Occult systemic lupus erythematosus with active lupus nephritis presenting as libman-sacks endocarditis. |
| PubMedID- 26573552 | Systemic lupus erythematosus patients with lupus nephritis (ln) who progress to eskd in the united states are mostly female (81%) and of african ancestry (49%), with a mean age of 41 years at initiation of renal replacement therapy (rrt). |
| PubMedID- 23127285 | Allogenic mesenchymal stem cell transplantation ameliorates nephritis in lupus mice via inhibition of b-cell activation. |
| PubMedID- 25249721 | In summary, we have presented a case of lupus cystitis with nephritis, an uncommon manifestation of sle mainly reported in south asians. |
| PubMedID- 23049599 | S. yung and t. m. chan review several of the main types of lupus autoantibodies closely associated with nephritis and the results of the interactions of these pathogenic antibodies with resident kidney cells, while y. shen et al. |
| PubMedID- 22740328 | Objective: autoantibodies against c1q strongly correlate with the occurrence of severe nephritis in patients with systemic lupus erythematosus (sle). |
| PubMedID- 20132967 | Objectives: to describe the unusual occurrence of systemic lupus erythematosus (sle) with nephritis in human immunodeficiency virus (hiv)-infected individuals. |
| PubMedID- 25095657 | Aim: to analyze the prognostic value of the polymorphisms of the thrombophilic genes: plasminogen activator inhibitor type 1 (pai-1) (-675 4g/5g), factor xiii (fxiii) (g485t), fibrinogen (fbg) (g(-455)a), glycoprotein ia (gpia) (c807t), glycoprotein iiia (gpiiia) (t106c), and p22phox (c242t), as well as protein genes involved in the pathogenesis of endothelial dysfunction: subunits of p22phox nadh-oxidase (p22phox) (c242t), endothelial no-synthase (enos) (g894t), and methylenetetrahydrofolate reductase (mthfr) (c677t) for the development of antiphospholipid syndrome (aps) and a type of progressive lupous nephritis (ln) in patients with systemic lupus erythematosus (sle). |
| PubMedID- 22467656 | Aberrant macrophages mediate defective kidney repair that triggers nephritis in lupus-susceptible mice. |
| PubMedID- 25890083 | As typically seen in sle, scurfy mice developed mesangioproliferative glomerulonephritis meeting the criteria of who class ii lupus nephritis, which may have been overlooked in previous analysis if sections were not specifically stained with pas or by if [42]. |
| PubMedID- 22096364 | Recently, measurement of messenger rna (mrna) expression in urinary sediment has been described,71 and it was shown that urinary mrna and protein expressions of t-bet were significantly higher in lupus with active nephritis compared with those with inactive disease. |
| PubMedID- 22286140 | Methods: female nzbxnzw f1 mice develop lupus-like disease with extensive nephritis that finally leads to lethal renal failure. |
| PubMedID- 22249649 | Furthermore, immune complex glomerulonephritis with features resembling lupus nephritis has been described in hiv-positive patients. |
| PubMedID- 25258482 | The tgf-beta1 cytokine concentration is known to be higher in nephritis with implied lupus nephritis severity. |
| PubMedID- 22026341 | Systemic lupus erythematosus with severe nephritis that mimicked henoch-schoenlein purpura. |
| PubMedID- 22888407 | Despite that, the diagnostic of nephritis compatible with lupus by biopsy (in the presence of sle antibodies) is enough for classification. |
| PubMedID- 26549923 | Found a significantly increased frequency of the fcγriia-r131 allele in lupus patients with nephritis and the patients whom anti-c1q antibodies were detected in their sera, as compared with controls, suggesting that fcγriia-r131 was associated with production of anti-c1q antibodies and might be a risk factor for the development of sle with manifestations in the kidney in caucasoid patients [57]. |
| PubMedID- 22192660 | Similarly, in lupus patients with nephritis, macrophage infiltration in the kidney correlates with disease [70] (reviewed in [71]). |
| PubMedID- 23642011 | Therefore, the study to evaluate ocrelizumab in patients with nephritis due to systemic lupus erythematosus (belong) trial was suspended[20]. |
| PubMedID- 25914407 | Combined transplantation of autologous hematopoietic stem cells and allogenic mesenchymal stem cells increases t regulatory cells in systemic lupus erythematosus with refractory lupus nephritis and leukopenia. |
| PubMedID- 26234005 | Systemic lupus erythematosus with stage iv nephritis in an african girl. |
| PubMedID- 25535434 | [27] systemic lupus erythematosus with nephritis does not respond well by adding tpe to cyclophosphamide. |
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