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PedAM

Pediatric Disease Annotations & Medicines




Disease lupus
Phenotype C0024312|lymphopenia
Sentences 4
PubMedID- 26170228 Objective: to systematically review the available evidence to evaluate (1) the prevalence and degree of leukopenia, lymphopenia, and neutropenia in patients with systemic lupus erythematosus (sle), (2) whether these conditions carry a major infection risk for patients, and (3) whether a treatment with colony stimulating factors (csf) can be an effective and safe option in sle patients with leukopenia.
PubMedID- PMC4042543 Investigations demonstrated lymphopenia, prolonged aptt with positive lupus anticoagulant and anticardiolipin antibodies, raised immunoglobulin levels, low c4, persistently raised esr but normal crp as well as strongly positive ana(1:2560) and anti-dna antibody(86 iu/ml).
PubMedID- 23525305 In contrast, the efficacy of the h1n1 pandemic vaccine was impaired in lupus patients with lymphopenia (19), and in hiv-infected individuals, a lower mean nadir cd4 cell count and longer duration of infection were associated with reduced seroconversion (20).
PubMedID- 24070661 lymphopenia helps early diagnosis of systemic lupus erythematosus for patients with psychosis as an initial symptom.

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