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PedAM

Pediatric Disease Annotations & Medicines




Disease lupus
Phenotype C0020455|hypergammaglobulinemia
Sentences 4
PubMedID- 26131743 Mrl/lpr mice develop a spontaneous autoimmune disease that closely resembles human systemic lupus erythematosus (sle) with dna autoantibodies, hypergammaglobulinemia, immune complex glomerulonephritis, and systemic vasculitis.
PubMedID- 25390704 Unusual maculopathy secondary to hypergammaglobulinemia in a patient with systemic lupus erythematosus.
PubMedID- 20668674 Ro52-deficient mice, following tissue injury, develop symptoms including severe dermatitis, systemic lupus with hypergammaglobulinemia and autoantibodies to dna, indicating that a loss of ro52 can cause a lupus-like disease [26].
PubMedID- 26241228 In a review of 33 patients with a monoclonal-protein-associated maculopathy, 20 of the patients had waldenström macroglobulinemia, 8 had myeloma, 2 had light chain deposition disease, 1 had hypergammaglobulinemia associated with systemic lupus erythematosus, 1 had polyclonal hypergammaglobulinemia without a known underlying cause, and 1 patient had polyneuropathy organomegaly endocrinopathy m-protein and skin abnormalities syndrome (poems).45 nine of the patients had unilateral involvement.

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