PedAM
Pediatric Disease Annotations & Medicines
| Disease | lung disease |
| Phenotype | C0004623|bacterial infection |
| Sentences | 7 |
| PubMedID- 25734087 | We describe 3 mucormycosis cases with an uncommon presentation in patients whose cavitary lung disease was attributed to well documented bacterial infection, although evolution and reassessment established mucormycosis as the underlying disease. |
| PubMedID- 20967843 | We hypothesized that other epithelial channels affecting salt balance across the airways may play a role in the susceptibility to bacterial infections and modulate severity of cf lung disease. |
| PubMedID- 22334793 | The achilles heel of cf is the infected lung with reduced clearance of bacteria, fungi, and viruses, causing progressive lung disease associated with unremitting bacterial infection, predominantly p. aeruginosa.53 the gene defect in cf affects macrophages globally due to the lack of cftr regulation, reducing the important phagosomal acidification and causing a reduced bactericidal activity triggered by the altered alveolar microenvironment, as underlined by the fact that the cf patient does not have an increased rate of systemic infections.54 loss of intracellular acidification in cftr-deficient alveolar macrophages could therefore be the explanation for the enhanced survival of bacterial loads within the phagosomal compartment.55 this apparent discrepancy between reduced alveolar macrophage function and lack of global infections may seem puzzling. |
| PubMedID- 23750235 | Petrii was identified from four sequential respiratory samples and a post-mortem spleen sample of a woman presenting with bronchiectasis and cavitary lung disease associated with nontuberculous mycobacterial infection. |
| PubMedID- 24603807 | Chronic bacterial infections associated with cf lung disease have been studied by a range of culture-independent profiling methodologies [6]–[12], and each approach has revealed greater microbial diversity than was previously recognized. |
| PubMedID- 21054862 | Conclusions: our data for the first time suggest that airway epithelial tlr2 signaling is pivotal in mycoplasma-induced splunc1 production, thus improving our understanding of the aberrant splunc1 expression in airways of patients suffering from chronic lung diseases with bacterial infections. |
| PubMedID- 25822969 | bacterial infections in patients with chronic lung diseases, such as asthma and copd, can severely impact on their quality of life and lead to hospital admissions. |
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