PedAM
Pediatric Disease Annotations & Medicines
| Disease | lung cancer |
| Phenotype | C1704231|leptomeningeal metastases |
| Sentences | 2 |
| PubMedID- 21865399 | We previously reported that intermittent "pulsatile" administration of high-dose (1500 mg) erlotinib once weekly was tolerable and achieved concentrations in cerebrospinal fluid exceeding the half maximal inhibitory concentration for egfr mutant lung cancer cells in a patient with leptomeningeal metastases; we now expand this paradigm to a series of 9 patients. |
| PubMedID- 25248713 | The paper make a review of research progress in pathologic physiology, clinical manifestations, diagnosis methods and treatments of lung cancer with leptomeningeal metastases. |
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