PedAM
Pediatric Disease Annotations & Medicines
| Disease | lung cancer |
| Phenotype | C0220650|brain metastases |
| Sentences | 91 |
| PubMedID- 23958057 | High plasma fibrinogen concentration and platelet count unfavorably impact survival in non-small cell lung cancer patients with brain metastases. |
| PubMedID- 23065044 | This study evaluated the efficacy of gks for treating brain metastases associated with small-cell lung cancer (sclc) after whole-brain radiotherapy (wbrt) as the first-line radiation therapy. |
| PubMedID- 24496139 | I started looking [for information] 2 weeks after the definitive diagnosis of lung cancer with brain metastases had been made. |
| PubMedID- 26114639 | Background: the role of surgical treatment of lung cancer with brain metastases remains controversial. |
| PubMedID- 22490154 | [evaluation of gefitinib plus radiotherapy in non-small-cell lung cancer patients with brain metastases]. |
| PubMedID- 21766491 | Purpose: to evaluate the clinical and radiologic response rates, toxicity and tolerability of 2x8 gy whole brain radiotherapy (wbrt) in lung cancer patients with brain metastases (bm). |
| PubMedID- 25842091 | Treatment and control of brain metastases are important in patients with non-small cell lung cancer (nsclc). |
| PubMedID- 23110940 | Survival of non-small cell lung cancer patients with brain metastases treated with brain rt stratified by egfr mutation status. |
| PubMedID- 23376611 | Bevacizumab is now allowed for non-small cell lung cancer (nsclc) patients with brain metastases and non-squamous histology. |
| PubMedID- 19740564 | In conclusion, mgmt expression was enhanced in brain metastases as compared with the primary lung cancers. |
| PubMedID- 19592127 | Can upfront systemic chemotherapy replace stereotactic radiosurgery or whole brain radiotherapy in the treatment of non-small cell lung cancer patients with asymptomatic brain metastases. |
| PubMedID- 26315660 | brain metastases develop in one-third of patients with non-small-cell lung cancer and are associated with a dismal prognosis, irrespective of surgery or chemo-radiotherapy. |
| PubMedID- 26520640 | We prospectively addressed whether egfr and kras mutations, eml4-alk, ros1 and ret rearrangements, or wild-type (wt), affects radiosurgery outcomes and overall survival (os) in non-small cell lung cancer (nsclc) patients with brain metastases (bm). |
| PubMedID- 25628027 | Squamous cell histology was associated with worse prognosis after resection of brain metastases in patients with non-small cell lung cancer. |
| PubMedID- 23128816 | Correlation between brca1 expression and clinicopathological factors including brain metastases in patients with non-small-cell lung cancer. |
| PubMedID- 20591632 | Aims: to study various prognostic factors affecting outcome and to validate radiation therapy oncology group recursive partitioning analysis (rpa) class in non-small cell lung cancer (nsclc) with brain metastases treated with short-course accelerated radiotherapy (scar). |
| PubMedID- 23133721 | Multiple gamma knife radiosurgery for multiple metachronous brain metastases associated with lung cancer : survival time. |
| PubMedID- 24649230 | The histological type of lung cancer in patients with brain metastases may affect response to treatment and survival. |
| PubMedID- 25347291 | Whole brain radiotherapy plus concurrent chemotherapy in non-small cell lung cancer patients with brain metastases: a meta-analysis. |
| PubMedID- 26359696 | Objective: we used brain radiotherapy as a surrogate for the presence of brain metastases in patients with non-small cell lung cancer (nsclc) to determine the prevalence of brain metastases using the surveillance epidemiology and end results database. |
| PubMedID- 24649011 | Therapeutic strategy for non-small-cell lung cancer patients with brain metastases (review). |
| PubMedID- 25925626 | Another trial84 examined the use of primary chemotherapy for newly diagnosed non-small cell lung cancer with synchronous brain metastases (with delayed wbrt at brain relapse) versus wbrt administered first. |
| PubMedID- 24019862 | The lung cancer patient lc1 with brain metastases had not been undergoing any treatment. |
| PubMedID- 23503999 | Though lung cancer with brain metastases is a possibility in patients presenting with chest tumor and altered mental states, solitary fibrous tumor (with hypoglycaemia) should also be considered. |
| PubMedID- 25208818 | The aim of this study was to explore prognostic factors for non-small cell lung cancer (nsclc) patients with brain metastases (bm) on the basis of egfr mutation status. |
| PubMedID- 20658721 | Gamma knife radiosurgery in non small cell lung cancer patients with brain metastases: treatment results and prognostic factors. |
| PubMedID- 24904894 | Outcome of surgical resection of symptomatic cerebral lesions in non-small cell lung cancer patients with multiple brain metastases. |
| PubMedID- 24606446 | Background: the incidence of brain metastases (bm) varies in patients with non-small cell lung cancer (nsclc), calls into question the value of prophylactic cranial irradiation (pci). |
| PubMedID- 22461932 | Past medical history was notable for small cell lung cancer (sclc) with brain metastases. |
| PubMedID- 22613338 | Background and objective: the aim of this study is to evaluate the efficacy of selected arterial infusion chemotherapy in treating non-small cell lung cancer (nsclc) with multiple brain metastases and corresponding factors to influencing prognosis. |
| PubMedID- 26218580 | Radiation-refractory brain metastases in patients with non-small cell lung cancer. |
| PubMedID- 25656857 | Systemic treatment of lung cancer patients with brain metastases is based on clinical (presence of symptomatic intracranial lesions), pathological and molecular characteristics of the disease. |
| PubMedID- 25364413 | The patient underwent whole-brain radiotherapy based on a tentative diagnosis of lung cancer with multiple brain metastases. |
| PubMedID- 21972711 | [the role of surgical treatment of primary non-small cell lung cancer with synchronous brain metastases]. |
| PubMedID- 26275366 | Delayed leukoencephalopathy of non-small cell lung cancer patients with brain metastases underwent whole brain radiation therapy. |
| PubMedID- 26469914 | The low cerebrospinal fluid (csf) concentration of reversible first-generation egfr tkis may be responsible for the high rates or recurrence and progression observed with these pharmacological agents.4,9,10 the higher csf concentration obtained with erlotinib led to its consideration as a treatment for brain metastases in patients with egfr-mutated lung cancer.3,4,9,10 pulsed high doses of egfr tkis are recommended in lung adenocarcinoma patients with resistance to previous egfr tki therapy, although there is a lack of clinical trials providing evidence to support this recommendation.4,10,11 afatinib has been shown to have a lower ic50 than the reversible first-generation egfr tki in in vitro studies.6 hoffknecht et al reported 2 cases from the acuc study. |
| PubMedID- 25313746 | Fractionated stereotactic radiotherapy for small-cell lung cancer patients with brain metastases. |
| PubMedID- 22118497 | Background: brain metastases occur in 30-50% of non-small cell lung cancer (nsclc) patients and confer a worse prognosis and quality of life. |
| PubMedID- 24256883 | Survival and treatment options are limited for patients with brain metastases arising from non-small cell lung cancer (nsclc). |
| PubMedID- 21924038 | The aim of this study is to explore prognostic factors in non-small cell lung cancer (nsclc) in patients with brain metastases diagnosed by constrast-enhanced mri after whole brain radiotherapy. |
| PubMedID- 25646356 | Objective: the incidence of brain metastases greatly varies in patients with non-small-cell lung cancer, and molecular markers are considered to predict brain metastases. |
| PubMedID- 22780988 | Developed a prognostic index for patients with wbrt for brain metastases of lung cancer and scored the factors age, ecog performance status, histology, weight loss, primary and systemic disease status [38]. |
| PubMedID- 20335119 | Objective: to establish a diagnostic model of protein fingerprint pattern in the cerebrospinal fluid (csf) for non-small-cell lung cancer (nsclc) patients with brain metastases. |
| PubMedID- 26199015 | Introduction: the prognostic value of egfr mutation in lung cancer patients with brain metastases is uncertain and therapeutic efficacy with egfr tki is limited. |
| PubMedID- 26553452 | Most lung cancer patients with brain metastases have multiple lesions, and this is associated with a survival time of 3–6 months. |
| PubMedID- 25404274 | Targeted agents have become the novel methods for the treatment of lung cancer with brain metastases beyond the whole brain radiation therapy, stereotactic radiosurgery and chemotherapy. |
| PubMedID- 26407999 | brain metastases arising from primary lung cancer contribute significantly to the morbidity and mortality of the disease. |
| PubMedID- 20604919 | As a further support to this hypothesis, increased her3 expression has also been reported in brain metastases of lung cancer [44]. |
| PubMedID- 21321089 | Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (nsclc) with asymptomatic inoperable brain metastases: a multicenter phase ii trial (gfpc 07-01). |
| PubMedID- 24790650 | This review is focused on the evidence for therapeutic strategies in bone and brain metastases due to lung cancer. |
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