PedAM
Pediatric Disease Annotations & Medicines
| Disease | lung cancer |
| Phenotype | C0007131|nsclc |
| Sentences | 62 |
| PubMedID- 24066116 | Non-small cell lung carcinoma (nsclc) accounts for most of the lung cancer cases and the prognosis of this disease remains poor despite decades of intensive investigation. |
| PubMedID- 24304228 | There was no restriction for age, gender, or disease stage at enrolment, but the study was restricted to patients with the nsclc type of lung cancer. |
| PubMedID- 23504373 | However, it is well known that lung cancer (mainly nsclc) is a genetically complex disease, developing in a result of the accumulation of multiple genetic abnormalities. |
| PubMedID- 22615840 | In conclusion, our study demonstrated that carma3 is overexpressed in nsclc and correlates with lung cancer progression. |
| PubMedID- 25640394 | Materials and methods: retrospectively, 130 patients were selected at the time of diagnosis oflung cancer (100 with nsclc and 30 with sclc), before the initialization of any chemo-radiotherapy. |
| PubMedID- 26176608 | nsclc, accounting for 80% of all lung cancers, includes squamous carcinoma, adenocarcinoma and large cell carcinoma. |
| PubMedID- 23369726 | nsclc accounts for 80% of clinical lung cancer cases, the remaining lung cancer cases are diagnosed as sclc. |
| PubMedID- 26400209 | Adenocarcinomas are nsclc, comprising 30–40% of all lung cancers (2). |
| PubMedID- 24204697 | Similarly, in contrast to nsclc, growth of small cell lung cancer cells (sclc) is driven through the establishment of neuropeptide autocrine loops [43]. |
| PubMedID- 24765144 | nsclc accounts for >85% of all lung cancer cases (2). |
| PubMedID- 23667589 | Non-small-cell-lung-cancer (nsclc) represents approximately 85% of all lung cancers and remains poorly understood. |
| PubMedID- 25859693 | Blood samples (plasma) in study 1 (fhcrc study) were taken from newly diagnosed lung cancer patients with nsclc adenocarcinoma (mostly late stage) and were frequency matched with for age, gender and for general smoking history (current and former smokers) (table 1a). |
| PubMedID- 23776618 | However, our previous studies in primary nsclc, a large number of human lung cancer cell lines, and primary tumor samples identified a region of homozygous deletion (hd) at the microsatellite marker d9s126 which is distinct from the p16/cdkn2a locus and lies approximately 3.7 mb proximal to p16/cdkn2a, [10], [14]. |
| PubMedID- 22500162 | Purpose: non-small cell lung carcinoma (nsclc) comprises 75-85% of all lung cancers, and approximately 25% of all nsclc patients develop brain metastasis. |
| PubMedID- 24172710 | Despite the inherent poor prognosis of sclc, surgically resected patients with sclc have 5-year survival of 31% compared with 45% in resected nsclc and 3% in patients with unresected lung cancer of either subtype. |
| PubMedID- 26048572 | We performed immunostaining for lmo4 in nsclc tissue-microarray (tma) of lung cancer samples obtained from patients undergoing lung cancer surgery (stage i-ii disease) comprising 34 squamous cell carcinomas, 40 adenocarcinomas and ten otherwise-classified nsclcs including large cell carcinomas. |
| PubMedID- 23369236 | Together, these five diseases accounted for over 50% of all cancer deaths in the united states in 2009. lung cancer alone, with nsclc as the most common cause of worldwide cancer premature death, killed over 160,000 people, more than the other four cancers put together. |
| PubMedID- 24150265 | Patients with advanced stage, non-squamous nsclc comprised half of all lung cancer patients. |
| PubMedID- 25663868 | As aforementioned, nsclc accounts for ~80% of all lung cancer subtypes (3). |
| PubMedID- 24564251 | Other molecules in the map are shared by nsclc and general events of lung cancers. |
| PubMedID- 22179630 | In china, nsclc accounts for 80–85% of lung cancers and most patients (>70%) at the time of diagnosis are at unresectable iiib or iv stage. |
| PubMedID- 24396506 | Because sclc metastasizes earlier and is initially more chemosensitive than nsclc, the two types of lung cancer are treated differently. |
| PubMedID- 23226738 | Approximately 40% of lung cancer patients present with advanced nsclc (1). |
| PubMedID- 23486533 | nsclc comprises about 80% of all lung cancers. |
| PubMedID- 23497017 | nsclc accounts for 80% of lung cancers and has a propensity to metastasize and to be resistant to chemotherapy and radiation therapy[1,2]. |
| PubMedID- 21595568 | Context: nonsmall cell lung cancers with neuroendocrine differentiation (nsclc-nd) may demonstrate biologic behavior intermediate between nsclc and small cell lung cancer (sclc) with impact on prognosis. |
| PubMedID- 22385677 | nsclc represents almost 80% of lung cancer, which is the leading cause of cancer-related death in the world. |
| PubMedID- 25561901 | nsclc comprises about 80% of all diagnosed lung cancer, and lung adenocarcinoma is the most common subtype of nsclc 2. among patients with lung cancer, 70% present with advanced-stage disease when diagnosed, which has already spread locally or to distant organs 3. while targeted therapy, based on patient-specific molecular aberrations, has recently led to significant responses in lung adenocarcinomas 4, 5, about half of the lung cancer patients do not harbor known driver mutations and cannot be treated with targeted therapy 6. therefore, novel insights into the molecular mechanisms underlying lung adenocarcinoma pathogenesis as well as regulators and potential targets for treatment are critically needed. |
| PubMedID- 21575235 | Non-small cell lung carcinoma (nsclc) accounts for 80% of lung cancer and is further subdivided into two major types, squamous cell carcinoma and adenocarcinoma [2]. |
| PubMedID- 23947765 | nsclc comprises 85% of lung cancer cases and about 40% are unresectable [2]. |
| PubMedID- 25725930 | These results suggest that surgical resection can be considered for patients who have a second primary nsclc after resection of an initial lung cancer. |
| PubMedID- 23343191 | However, in contrast to its high activity in sclc, doxorubicin is not curative in nsclc which represents 4/5 of all lung cancers [13]. |
| PubMedID- 22773695 | Non-small cell lung carcinoma (nsclc) accounts for most of all lung cancers, which is the leading cause of mortality in human beings. |
| PubMedID- 24744457 | Expression of mir-21, mir-29b, mir-34a/b/c, mir-155, and let-7a was determined from 639 ialt (the international adjuvant lung cancer trial) patients with nsclc, finding no significant association between any of the tested mirnas and survival, with the exception of mir-21 for which a deleterious prognostic effect of lowered expression was suggested [177]. |
| PubMedID- 24524655 | nsclc accounts for 80-85% of all lung cancers. |
| PubMedID- 26273330 | Found that levels of ldhb were specifically elevated in nsclc sera compared with non-lung cancer and benign lung disease, as well as in healthy individuals, and progressively increased with clinical stage.40 this finding could offer novel biomarkers related to lung cancer migration and invasion. |
| PubMedID- 24639950 | Os and lung cancer-specific survival (lcss) in patients with stage i nsclc diagnosed from 2004 to 2009 were analyzed to determine the effects of age and treatment. |
| PubMedID- 26010604 | nsclc comprises 85% of all lung cancer cases, with adenocarcinoma (ac) representing the major histological subtype of nsclc [1]. |
| PubMedID- 25926075 | Tumor specimens were obtained from lung cancer patients diagnosed with nsclc in accordance with the local ethics committee. |
| PubMedID- 21897855 | In non-small cell lung carcinoma (nsclc), overexpression of il-22 protected lung cancer cell lines from apoptosis, while downregulation of il-22 significantly inhibited the human tumor cell growth in balb/c nude mice [13]. |
| PubMedID- 23254764 | nsclc represents 80% of lung cancers. |
| PubMedID- 24577055 | nsclc represents ∼85% of all lung cancers and adenocarcinoma is the most common subtype of nsclc (travis et al, 2011). |
| PubMedID- 20414943 | Conclusion: it seems that scintigraphy with (99m)tc-depreotide in patients with sclc does not change the tumor stage, whereas in nsclc the contribution of neospect in lung cancer staging may be a helpful tool, especially in cases where ct alone is unable to distinguish between iiia and iiib stages (operable from non operable status). |
| PubMedID- 20497582 | nsclc accounts for 80%-85% of all lung cancers [1]. |
| PubMedID- 26011146 | nsclc accounts for 85%-90% of lung cancers and contains three main subtypes: squamous cell (epidermoid) carcinoma, adenocarcinoma and large cell (undifferentiated) carcinoma. |
| PubMedID- 25853010 | nsclc represents approximately 80% of lung cancer cases, and over 60% of these tumors express the epidermal growth factor receptor (egfr), rendering it a primary protein of interest of different targeted therapeutic approaches [1,3-5]. |
| PubMedID- 24872958 | nsclc represents about 80% of all lung cancer cases and includes three histological subtypes: squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. |
| PubMedID- 25945061 | About 40%–85% of lung cancer tissue specimens in patients with nsclc were detected in egfr expression or high expression, and lesions in patients with high expression of egfr progress more quickly and not sensitive to chemotherapy or radiotherapy as well as show poor prognosis.12 at present, gefitinib and erlotinib are the most common egfr tkis and are widely used in the treatment of patients with advanced nsclc with mild adverse effects, and can significantly improve the quality of life. |
| PubMedID- 21811665 | nsclc comprises approximately 80% of all lung cancers and can be classified into adenocarcinoma (ac), squamous cell carcinoma (sqcc), and large cell carcinoma, whereas sclc tends to spread more quickly than nsclc and can be divided into small cell carcinoma (scc), mixed small cell/large cell carcinoma, and combined small cell carcinoma. |
| PubMedID- 21695068 | nsclc accounts for 80% of all lung cancer cases. |
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