PedAM
Pediatric Disease Annotations & Medicines
| Disease | liver failure, acute |
| Phenotype | C0001125|lactic acidosis |
| Sentences | 3 |
| PubMedID- 22267946 | The drug was virologically effective but it led to a high incidence of subacute liver failure with symptomatic lactic acidosis.19 the toxic effect was found to be mitochondrial toxicity related to inhibition of the effect of dna polymerase γ, the dna polymerase involved in mitochondrial function. |
| PubMedID- 24826316 | Throughout that day, the patient developed fulminant liver failure with a severe lactic acidosis and disseminated intravascular coagulopathy and required intubation. |
| PubMedID- 22893751 | Although the drug was effective, it led to a high incidence of subacute liver failure with symptomatic lactic acidosis, and the toxic effect was found to be mitochondrial toxicity relating to inhibition of the effect of dna polymerase gamma, the dna polymerase involved in mitochondrial function.58 a single-nucleotide polymorphism in the resistin gene has been shown to be associated with a cluster of metabolic alterations, including insulin resistance, dyslipidemia, and lipoatrophy in patients receiving art.59 the identification of lipodystrophy has had significant implications on the management of hiv, and its recognition as a side effect of art has led to reevaluation of the appropriate time to start art, delay initiation of art, and also to different modifications in art for hiv treatment. |
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