PedAM
Pediatric Disease Annotations & Medicines
| Disease | lactic acidosis |
| Phenotype | C0751651|mitochondrial diseases |
| Sentences | 1 |
| PubMedID- 23471124 | As first described in 1969 by stacpoole (stacpoole, 1969), by inhibiting pdk and coupling glycolysis to go, dca could lower lactate levels and the symptoms associated with lactic acidosis in patients with mitochondrial diseases, mostly syndromes caused by the lack or decreased expression of critical enzymes involved in go, like pdh. |
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