PedAM
Pediatric Disease Annotations & Medicines
| Disease | lactic acidosis |
| Phenotype | C0751651|mitochondrial disease |
| Sentences | 2 |
| PubMedID- 23742928 | Yet it has been shown that exercise intolerance and sympathetic activation are independent of lactic acidosis in patients with mitochondrial disease [69,70]. |
| PubMedID- 23471124 | As first described in 1969 by stacpoole (stacpoole, 1969), by inhibiting pdk and coupling glycolysis to go, dca could lower lactate levels and the symptoms associated with lactic acidosis in patients with mitochondrial diseases, mostly syndromes caused by the lack or decreased expression of critical enzymes involved in go, like pdh. |
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