PedAM
Pediatric Disease Annotations & Medicines
| Disease | kidney cancer |
| Phenotype | C0011847|diabetes |
| Sentences | 3 |
| PubMedID- 24797175 | A significant increase in ki67 expression was detected by western blot analysis in kidney cancer tissue with or without diabetes while a slight increase was detected in kidney tissue of diabetic patient (fig. |
| PubMedID- 26559055 | Multivariable-adjusted odds ratios for kidney cancer with regards to diabetes status and diabetes duration (as a continuous variable or categorized into subgroups of non-diabetes, diabetes duration <1 year, 1–2.9 years, 3–4.9 years and ≥5 years) were estimated after multivariable adjustment. |
| PubMedID- 26131819 | It is unclear whether the association is direct or due to share the common metabolic risk factors such as the obesity, which was considered an important factor in cancer development and progression.36 recently, a study by habib et al suggests that the accumulation of oxidative dna damage, which was increased through the hyperactivation of akt/tuberin/mtor pathway in kidney cancer patients with diabetes, may play an important role in initiating kidney tumorigenesis.37 another convincing mechanism presumed as the effect of hyperglycemia and hyperinsulinemia, which can result in enhanced production of insulin-like growth factor-i (igf-1) in the liver.38,39 apart from being a potent mediator of tumor cell migration and invasion, igf-1 is also central in cell proliferation and differentiation.39 increased activation of the igf-1 signaling pathway has been implicated in many human malignancies including renal cancers.40 moreover, the pathway of igf-1 and its receptor was identified as a major promoter of tumor invasion and metastases in in vitro and in vivo studies.41,42 these above discoveries support our results stating that dm is associated with poor rcc prognosis, and may lead to the proposal that inhibiting the igf-1 signaling pathway could represent a novel therapeutic strategy. |
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