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PedAM

Pediatric Disease Annotations & Medicines




Disease ischemia
Phenotype C0033687|proteinuria
Sentences 2
PubMedID- 21862236 It is hypothesized that in some women an excessively high intra-abdominal pressure (iap) compresses the inferior vena cava, uterine veins, portal vein, hepatic veins, splenic vein and renal veins which lead to a decreased flow in these vascular beds, producing lower extremity edema, fetal-placental ischemia, a glomerulopathy with proteinuria and hypertension, hepatic ischemia and thrombocytopenia, increased uric acid, and hemolysis/elevated liver enzymes/low platelet known as the hellp syndrome.
PubMedID- 24625990 Glomerular disease with proteinuria may develop due to ischemia and results in a compensatory increase in the renal blood flow and glomerular filtration rate; such hyperfiltration, combined with glomerular hypertrophy, probably contributes to glomerulosclerosis.

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