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PedAM

Pediatric Disease Annotations & Medicines




Disease ischemia
Phenotype C0032914|preeclampsia
Sentences 4
PubMedID- 22195275 We have recently demonstrated that induction of the ho-1 pathway could significantly attenuate the preeclampsia-like pathological manifestations associated with experimental placental ischemia in the rodent.
PubMedID- 24159378 Hypertension in preeclampsia is associated with placental ischemia-induced release of antiangiogenic soluble fms-like tyrosine kinase (sflt-1) into the maternal circulation, which antagonizes vascular endothelial growth factor (vegf) promoting endothelial dysfunction.
PubMedID- 26444006 These data suggest that preeclampsia associated with placental ischemia and late hypoxic events may be responsible for the diminished content of placental aromatase observed in preeclamptic patients.
PubMedID- 21855848 Conclusion: patients with preeclampsia with sonographic evidence of chronic uteroplacental ischemia have high fetal plasma concentrations of adenosine.

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