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PedAM

Pediatric Disease Annotations & Medicines




Disease ischemia
Phenotype C0029128|optic disc drusen
Sentences 1
PubMedID- 23658477 While asymptomatic in most cases, transient visual obscuration may occur in patients with optic disc drusen due to transient ischemia of the optic nerve head as a result of increased tissue pressure.27 although impairment of visual acuity as a result of optic disc drusen is rare, slowly progressive visual field loss (enlarged blind spot, arcuate defects, peripheral depression) may occur as a direct consequence of axonal compression, but is often unnoticed by the patient.28–30 occasionally, a more acute visual loss may occur, sometimes involving the central vision.31 this may be the result of local vascular complications such as central retinal artery and vein occlusion,32,33 and naaion,1–3 which can occur in the absence of any associated vascular disorder.28,34 these complications have been postulated to be due to the compressive effect of drusen on the blood vessels.27,34 in addition, both naaion and optic disc drusen have been associated with a small scleral canal that leads to axonal crowding and secondary vascular compromise.

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