PedAM
Pediatric Disease Annotations & Medicines
| Disease | ischemia |
| Phenotype | C0020456|hyperglycemia |
| Sentences | 6 |
| PubMedID- 21904663 | The results of our study elucidate the role of hyperglycemia in ischemia reperfusion injury during renal transplantation and have clinical implications for the perioperative management of glucose levels. |
| PubMedID- 20636251 | Data from our studies and other laboratories demonstrate that ischemia with concomitant hyperglycemia exaggerates the activation of extracellular signal-regulated kinase (erk) (2,5), which in turn can be activated by intermediates of reactive oxygen and nitrogen species (rons) (6). |
| PubMedID- 25660722 | Incorporating long-term degradation of blood supply from the retinal capillaries into the model yields insight into the effects of progressive ischemia associated with prolonged hyperglycemia, suggesting time-scales over which therapeutic mitigation could have beneficial effect. |
| PubMedID- 23091615 | We propose that ischemia-reperfusion together with hyperglycemia trigger greater oxidative stress that may result in increased misfolded proteins that are targeted for removal by ups degradation. |
| PubMedID- 25328819 | Several studies have demonstrated that hyperglycemia enhances the generation of rosduring ischemia-reperfusion process [19,20]. |
| PubMedID- 26301160 | hyperglycemia interacts with ischemia in a synergistic way on wound repair and myofibroblast differentiation. |
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