PedAM
Pediatric Disease Annotations & Medicines
| Disease | ischemia |
| Phenotype | C0002395|alzheimer\'s disease |
| Sentences | 3 |
| PubMedID- 23519520 | Sporadic alzheimer's disease begins as episodes of brain ischemia and ischemically dysregulated alzheimer's disease genes. |
| PubMedID- 26256964 | Triflusal also exerts multiple effects on platelet adhesion and aggregation.24 although it inhibits platelet prostaglandin g/h-synthase, triflusal is a weaker inhibitor than aspirin; therefore, it does not significantly reduce prostacyclin synthesis by endothelial prostaglandin g/h-synthase.25 both triflusal and its main active metabolite, 3-hydroxy-4-trifluoro-methylbenzoic acid, inhibit degradation of platelet and endothelial cyclic adenosine monophosphate, which subsequently limits intracellular calcium mobilization and platelet-endothelial cell interactions.2426 they also inhibit prostaglandin g/h-synthase-2 expression while activating transcription factor nuclear factor (nf)-κb and nf-κb-induced inflammatory mediators, such as vascular cell adhesion molecule-1.27 one study reported that triflusal inhibits nuclear factor of activated t-cells (nfat)-mediated transcription at a therapeutically relevant concentration, while aspirin inhibits nfat transactivation only at a high concentration.28 moreover, triflusal enhances no synthesis in neutro-phils, leading to an increased vasodilatory potential.29 a recent in vitro study found that administration of endothelin-1 in app23 transgenic mice triggered endothelin-induced ischemia along with increases in alzheimer's disease pathological markers in the region of the infarct, and triflusal reduced inflammation surrounding the endothelin-induced infarct.30 it appears that the vasodilation effect, anti-inflammatory effect of triflusal, and prevention of vasoconstriction caused by endothelin-1 ameliorates symptoms of pvd and improved blood circulation. |
| PubMedID- 20155452 | Focal cerebral ischemia induces alzheimer's disease-like pathological change in rats. |
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