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PedAM

Pediatric Disease Annotations & Medicines




Disease intellectual disability
Phenotype C0036341|schizophrenia
Sentences 3
PubMedID- 22958593 Mild to borderline intellectual disability in individuals with schizophrenia is also associated with a higher incidence of negative, compared to positive, symptoms by meta-analysis [86], although this study did not consider effects on premorbid phenotypes.
PubMedID- 24802306 Exclusionary criteria include the following conditions: (1) diagnosis or physical signs of genetic conditions/syndromes (for example, fragile x syndrome), (2) significant medical or neurological conditions affecting growth, development or cognition (for example, cns infection, seizure disorder, congenital heart disease), (3) sensory impairments such as vision or hearing loss, (4) low birth weight (<2000) or prematurity (<36 weeks gestation), (5) evidence of significant perinatal brain injury or exposure to in-utero neurotoxins (for example, alcohol, selected prescription medications), (6) non-english speaking families, (7) contraindication for mri (magnetic resonance imaging; for example, metal implants), (8) adopted children and (9) family history of first-degree relative with intellectual disability (not associated with asd), psychosis, schizophrenia or bipolar disorder.
PubMedID- 24115684 A genome wide survey supports the involvement of large copy number variants in schizophrenia with and without intellectual disability.

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