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PedAM

Pediatric Disease Annotations & Medicines




Disease hypothyroidism
Phenotype C0020676|hypothyroidism
Sentences 5
PubMedID- 24872812 Epidemiological studies have demonstrated increased cv events and mortality in subjects with subclinical as well as overt hypothyroidism, proposing substantial impact of thyroid insufficiency on atherosclerotic vascular changes in a graded manner [5].
PubMedID- 22242190 The second group displayed a severe phenotype comparable to that observed in age-matched pax8(cre/+); dicerflox/flox mice, with hypothyroidism associated with low t4 plasma levels (0,47±0,386 µg/dl, figure 4b), disruption of thyroid architecture (figure 4e) and post-weaning lethality.
PubMedID- 22837913 [5] critical illness during acute phase can mimic secondary hypothyroidism with low t4 and tsh levels, and tsh can rise during the recovery phase, with values reaching levels of primary hypothyroidism.
PubMedID- 23397938 The neonatal laboratory evaluation showed central hypothyroidism with a low t4 of 2.1 mug/dl (4.5-11.5) and an inappropriately normal tsh of 0.98 uiu/ml (0.5-4.5); undetectable growth hormone, igf-i, and igfbp3; a normal cortisol level; and a normal gonadotropin surge.
PubMedID- 21521256 Diagnosis and treatment of hypothyroidism in tsh deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine.

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