PedAM
Pediatric Disease Annotations & Medicines
| Disease | hypothyroidism |
| Phenotype | C0020443|hypercholesterolemia |
| Sentences | 9 |
| PubMedID- 23626955 | There was a deranged lipid profile in the hypothyroid patients, with hypercholesterolemia characterised by a significantly raised levels of cholesterol and cholesterol rich lipoproteins and raised atherogenic apo –b levels and reduced cardio – protective apo – a1. |
| PubMedID- 24288742 | The combination of hypercholesterolemia with hypothyroid status caused more pronounced changes in the lipid spectrum and atherogenic index and more pronounced lytic and necrobiotic changes in cardiomyocytes. |
| PubMedID- 25491211 | The association of hypercholesterolemia with overt-hypothyroidism is consistently reported,2 whereas hypercholesterolemia in subclinical hypothyroidism is debatable. |
| PubMedID- 23533949 | Hepatocellular damage due to fatty liver caused by hypercholesterolemia in hypothyroid patients causes high ast levels. |
| PubMedID- 23049165 | Serum hypercholesterolemia in hypothyroidism may cause bile to supersaturate in cholesterol. |
| PubMedID- 24396699 | Prescription of statins in patients with hypercholesterolemia associated with undetected hypothyroidism may cause severe rhabdomyolysis via additive interaction as shown in this case. |
| PubMedID- 26421178 | hypercholesterolemia in hypothyroidism is possibly due to the reduction of catabolism of lipoproteins, as a result of decreased number of lipoprotein receptors (9, 10). |
| PubMedID- 22205844 | Overt thyroid disease is associated with atherosclerotic cardiovascular disease; this is an unambiguous sign of overt hypothyroidism [7,8] and results from hypercholesterolemia and elevated blood pressure. |
| PubMedID- 25778649 | hypercholesterolemia in hypothyroid rats (thyroxine concentration 2-fold below the normal) was paralleled by a pronounced increase of the concentration of free circulating extracellular dna and total matrix metalloproteinases 2 and 7 activity. |
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