PedAM
Pediatric Disease Annotations & Medicines
| Disease | hypophosphatemia |
| Phenotype | C0029442|osteomalacia |
| Sentences | 12 |
| PubMedID- 19839770 | Furthermore, the hypophosphatemia associated with oncogenic osteomalacia and x-linked hypophosphatemia is accompanied by a decrease in 1,25-dihydroxyvitamin d and an increase in fibroblast growth factor 23 (fgf-23) levels,(16) which may contribute to impaired fracture healing. |
| PubMedID- 23350780 | hypophosphatemia with osteomalacia may be due to a neoplasm that produces fibroblast growth factor 23 (fgf-23), which inhibits phosphate reabsorption in the kidneys. |
| PubMedID- 24159011 | In cases of nonhereditary osteomalacia associated with hypophosphatemia and inadequate response to vitamin d supplementation, one should consider the possibility of tumor-induced osteomalacia, a paraneoplastic syndrome caused by small mesenchymal tumors often found in obscure locations. |
| PubMedID- 20729625 | We report one case in which osteomalacia with hypophosphatemia developed in a patient with chronic hepatitis b on adefovir dipivoxil at a low dose, 10 mg daily. |
| PubMedID- 24707470 | Among the causes, osteomalacia due to hypophosphatemia induced by the impaired absorption in the gastrointestinal tract, impaired re-absorption in the renal tubules, tumor and genetic diseases. |
| PubMedID- 20513948 | Fibroblast growth factor 23 (fgf23) belongs to fgf19 subfamily, whose members function like endocrine factors, and has a phosphaturic effect, leading to hypophosphatemia associated with rickets or osteomalacia when its concentration in blood is elevated. |
| PubMedID- 23565447 | [1] here, we present a case of severe osteomalacia, with predominant hypophosphatemia, presenting with progressive weakness, to the extent, enough to make him bed bound secondary to poor diet, and a lack of exposure to sunlight. |
| PubMedID- 25906239 | This results in hypophosphatemia with osteomalacia with stress fractures (looser zones) without osteolytic lesions, and with decreased energy metabolism resulting in muscle weakness. |
| PubMedID- 23451204 | For example, overproduction of fgf23 in osteoblastomas or stabilizing mutations in fgf23 protein is sufficient to cause hypophosphatemia, leading to osteomalacia or hypophosphatemic rickets in humans [5], [7]. |
| PubMedID- 24706031 | In human immunodeficiency virus (hiv)-infected patients, tenofovir disoproxil fumarate (tdf) may cause hypophosphatemia leading to osteomalacia due to renal phosphate wasting. |
| PubMedID- 26032529 | Imaging evidence of multifocal insufficiency fractures and metabolic disease on background of hypophosphatemia is attributed to hypophosphatemic osteomalacia from adefovir-induced renal proximal tubular dysfunction. |
| PubMedID- 26303287 | Thus, we conclude that the hypophosphatemia induced osteomalacia phenotype in dmp1 ko mice is contributed by at least two factors: the low pi level and the dmp1 local function in mineralization. |
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