PedAM
Pediatric Disease Annotations & Medicines
| Disease | hypogonadism |
| Phenotype | C0282193|iron overload |
| Sentences | 2 |
| PubMedID- 21772954 | The pituitary gland is one of the most vulnerable target organ to early toxic effects from iron overload, leading to hypogonadotropic hypogonadism in a large proportion of patients.47,66 pituitary r2 is closely correlated to liver and pancreatic iron, but not to heart iron. |
| PubMedID- 21668502 | This highlights that deferasirox can effectively control body iron burden without any growth-related safety concerns, which is important given that growth retardation and hypogonadism because of iron overload and dfo-induced toxicity are significant clinical problems in paediatric patients with β-thalassaemia (2, 3). |
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