PedAM
Pediatric Disease Annotations & Medicines
| Disease | hypoglycemia |
| Phenotype | C0020459|hyperinsulinism |
| Sentences | 17 |
| PubMedID- 22587661 | Such a fast enables 99% of hypoglycaemia cases associated with hyperinsulinism to be diagnosed. |
| PubMedID- 23274908 | Deletion of foxa2 in all β-cells caused severe neonatal hypoglycemia with relative hyperinsulinism (45) that was at least partly attributable to defects in katp channels (46). |
| PubMedID- 22759688 | A girl with intractable absence seizures and facial myoclonia at age 7 years was eventually diagnosed with hyperinsulinism-hyperammonemia syndrome because of hypoglycemia, hyperinsulinism, hyperammonemia, and the results of an oral l-leucine loading test. |
| PubMedID- 25870695 | A high level of glucose should trigger more attention as rebound hyperinsulinism could appear with subsequent severe hypoglycemia [4]. |
| PubMedID- 25618267 | Stress-related hyperinsulinism (hi) may lead to recalcitrant hypoglycemia for weeks or months following perinatal stress, often in premature newborn infants. |
| PubMedID- 24213240 | The diagnosis of insulinoma required a symptomatic hypoglycaemia (<40 mg/dl) with concomitant endogenous hyperinsulinism (>20 µu/ml) during a supervised fasting test and a positive immunohistochemistry for insulin in the tumor cells. |
| PubMedID- 19952738 | Studies of the cause of hypoglycemic brain damage and the relationship of hypoglycemia to disorders associated with hyperinsulinism have aided in our understanding of this common clinical finding. |
| PubMedID- 21086579 | The hypoglycemia is associated with an endogenous hyperinsulinism, also observed in a rare endocrine pathology, the insulinoma. |
| PubMedID- 26180531 | Congenital hyperinsulinism (chi) leads to hypoglycemia in infants and children due to inappropriately elevated insulin levels. |
| PubMedID- 24228030 | Insulin impairs igfbp-1 gene expression, and, as a consequence, high levels of igfbp-1 are present in diabetes mellitus [10] and low levels are noted during hypoglycaemia in patients with congenital hyperinsulinism [13]. |
| PubMedID- 25943194 | In the first 24 hours, the patient presented with hypoglycemia attributed to hyperinsulinism and was treated with diazoxide. |
| PubMedID- 26316438 | Unlike other congenital fatty acid oxidation defects, short-chain l-3-hydroxyacyl-coa (schad, hadh) deficiency is characterised by hypoglycemia with hyperinsulinism in the neonatal or infancy periods. |
| PubMedID- 26508374 | In this context, hypoglycaemia results from hyperinsulinism either generated by pancreas anomalies (nesidioblastosis) and/or caused by an overstimulation of beta cells by incretins, mainly glp-1. |
| PubMedID- 24616771 | Congenital hyperinsulinism (chi) leads to severe hyperinsulinaemic hypoglycaemia (hh) in the neonatal, infancy and childhood periods. |
| PubMedID- 24639276 | The hypoglycemia was attributable to hyperinsulinism and was treated with diazoxide and chlorothiazide. |
| PubMedID- 24728168 | In this paper, we describe two cases of hypoglycemia associated with endogenous hyperinsulinism, whose causes are uncommon in clinical practice, and review important aspects of the diagnosis and treatment of hyperinsulinemic hypoglycemia. |
| PubMedID- 24075522 | Discussion: nesidioblastosis is a rare pathology, but it must be present in the differential diagnosis of hypoglycemia symptoms with endogenous hyperinsulinism in adults, once the intake of sulfonylureas and possible pancreatic neoformations have been ruled out. |
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