PedAM

Pediatric Disease Annotations & Medicines

Disease	hypoglycemia
Phenotype	C0020459\|hyperinsulinemia
Sentences	17
PubMedID- 21414967	Severe hypoglycemia with endogenous hyperinsulinemia in a nondiabetic hemodialysis patient following parathyroidectomy.
PubMedID- 25692049	However, endogenous hyperinsulinemia with severe persistent hypoglycemia has not been reported with mdma use.
PubMedID- 23926410	In k-atp channel ko mice (kir6.2−/− and sur1−/−) or transgenic mice expressing adominant-negative form of kir6.2, hypoglycemia with hyperinsulinemia occurs in neonates followed byhyperglycemia with insulin secretory failure in adults (15,16,17,18).
PubMedID- 23274894	In contrast, glucokinase-activating mutations result in hyperinsulinemia, leading to hypoglycemia (39).
PubMedID- PMC3850401	Correct diagnosis for hypoglycemia cases with hyperinsulinemia needs not just blood test but also imaging or genetic testing.
PubMedID- 20923481	Background: hyperinsulinemia associated with non-ketotic hypoglycemia is observed in patients with mutated beta-oxidation enzyme short-chain 3-hydroxyacyl-coa dehydrogenase (hadhsc).
PubMedID- 23666968	Results: both subjects showed persistent evidence of hypoglycemia with marked hyperinsulinemia after the rygb reversal.
PubMedID- 25810037	Repeated episodes of hypoglycaemia are associated with hyperinsulinemia and diminished counterregulatory responses [5, 6], leading to impaired awareness of hypoglycaemia (iah) [2].
PubMedID- 24062772	On the other hand, the condition of hyperinsulinemia associated with hypoglycemia leads to the activation of the counterregulatory system with intensification of the release of glucagon and epinephrine [24].
PubMedID- 20592887	Deletion of the esp gene in mice (esp-/-) resulted in a high neonatal death rate from severe hypoglycemia associated with hyperinsulinemia and enhanced insulin sensitivity mediated by increased adiponectin production from adipocytes (20).
PubMedID- 22764512	Among the imaging methods in preoperative diagnostics of hypoglycemia with concomitant hyperinsulinemia somatostatin receptor scintigraphy seems to have specific, though limited role - it is valuable only in the severe, diffused lesions.
PubMedID- 24396652	The main causes of hypoglycemia combined with hyperinsulinemia are insulinoma, inappropriate use of antidiabetic agents, and autoimmune hypoglycemia.
PubMedID- 19934009	It is possible that prolonged hyperinsulinemia and/or recurrent episodes of insulin-induced hypoglycemia further increase vmh no production through a combined increase in nnos and enos activity.
PubMedID- 26399329	At the age of 3 years laboratory tests were performed and showed hypoglycemia with hyperinsulinemia (blood glucose 1.95–2.3 mmol/l; plasma insulin 5.5–10.2 μui/ml).
PubMedID- 23610061	Interestingly, mitfce/ce animals also had fasting hyperinsulinemia in the presence of slight hypoglycemia (fig.
PubMedID- 26558131	hyperinsulinemia with symptomatic hypoglycemia and relief of symptoms with glucose supply suggest insulinoma (whipple triad) [1].
PubMedID- 23691179	Moreover, txnip deficient mice show hyperinsulinemia with marked hypoglycemia during starvation [22], [23], further linking txnip to β-cell function.

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