PedAM
Pediatric Disease Annotations & Medicines
| Disease | hypersplenism |
| Phenotype | C0020541|portal hypertension |
| Sentences | 8 |
| PubMedID- 25538966 | Common indications of pse include hypersplenism with portal hypertension, hereditary spherocytosis, thalassemia, autoimmune hemolytic anemia, splenic trauma, idiopathic thrombocytopenic purpura, splenic hemangioma, and liver cancer. |
| PubMedID- 22480324 | This becomes important because it may help to explain the surprisingly low or normal blood counts observed in bcs jak2 v617f-positive patients; the subsequent hemodilution and hypersplenism resulting from the portal hypertension may decrease the actual hemoglobin and other blood cell counts, making the diagnosis of mpn quite challenging in many cases [4]. |
| PubMedID- 22540086 | In addition, the underlying cirrhosis present in most patients may lead to portal hypertension with hypersplenism, platelet sequestration, varices and gastrointestinal bleeding, hepatic encephalopathy, hypoalbuminemia, differential drug binding and distribution, and altered pharmacokinetics, limiting the selection and adequate dosing of most cytotoxic agents. |
| PubMedID- 22111083 | Among 19 patients who survived over 10 years after kpe, 6 (31.6%) patients suffered from portal hypertension; 2 with hypersplenism, and 4 with variceal bleeding. |
| PubMedID- 25755765 | Conclusion: subtotal splenectomy can eliminate the factors which precipitate splenomegaly (portal hypertension), improve the reconstruction of splenic capillaries, correct hypersplenism, and restore normal splenic function. |
| PubMedID- 23454561 | The incidence of hypersplenism in patients with cirrhosis and portal hypertension is high. |
| PubMedID- 23420139 | While in some patients the disease remained static, in a larger proportion a more severe disease developed characterized by portal hypertension, the latter leading to hypersplenism with neutropenia and thrombocytopenia and, in some cases, to ascites. |
| PubMedID- 24741213 | Mitra shunt (spleen preserving, side to side lieno-renal shunt) for portal hypertension with hypersplenism in early infancy. |
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