PedAM
Pediatric Disease Annotations & Medicines
| Disease | hypersplenism |
| Phenotype | C0002871|anemia |
| Sentences | 3 |
| PubMedID- 25789242 | Hepatic dysfunction can cause symptoms in the digestive system (impaired metabolism of carbohydrates, cholesterol, bile salts, esophageal varices, and gastrointestinal bleeding, among others), cardiovascular system (portal hypertension leading to right-side heart failure and in addition, ascites creating the third space ultimately, can severely reduce cardiac function and through different ways cause cardiomyopathy, blood pressure disorders especially hypotension are common in hepatic patients) (8, 9), respiratory system (ascites can be directly and through pressure to diaphragm can cause alveolar dysfunction, portal hypertension can lead to portopulmonary hypertension, in these patients the risk of aspiration is high) (10), the hematology system (anemia due to gastrointestinal bleeding, hypersplenism and hemolysis, malnutrition, disorders of coagulation and homeostasis due to decreased production of critical proteins in the liver) (11, 12), adrenal system (pre-renal azotemia and severe electrolyte disorder due to ascites) (9, 10), and central nervous system (hepatic encephalopathy). |
| PubMedID- 22043264 | hypersplenism can lead to anemia, leukopenia, and thrombocytopenia. |
| PubMedID- 20668714 | Splenomegaly is associated with hypersplenism leading to anemia and thrombocytopenia. |
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