PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperinsulinism |
| Phenotype | C0020598|hypoglycemia |
| Sentences | 19 |
| PubMedID- 25972930 | Diazoxide is the medication of choice for the treatment of hypoglycemia due to hyperinsulinism during the neonatal period. |
| PubMedID- 24075522 | Discussion: nesidioblastosis is a rare pathology, but it must be present in the differential diagnosis of hypoglycemia symptoms with endogenous hyperinsulinism in adults, once the intake of sulfonylureas and possible pancreatic neoformations have been ruled out. |
| PubMedID- 24728168 | In this paper, we describe two cases of hypoglycemia associated with endogenous hyperinsulinism, whose causes are uncommon in clinical practice, and review important aspects of the diagnosis and treatment of hyperinsulinemic hypoglycemia. |
| PubMedID- 19952738 | Studies of the cause of hypoglycemic brain damage and the relationship of hypoglycemia to disorders associated with hyperinsulinism have aided in our understanding of this common clinical finding. |
| PubMedID- 21086579 | The hypoglycemia is associated with an endogenous hyperinsulinism, also observed in a rare endocrine pathology, the insulinoma. |
| PubMedID- 21536946 | Inactivating mutations of the β-cell atp-sensitive k+ channel (katp channel) are the most common cause of hypoglycemia due to congenital hyperinsulinism (1). |
| PubMedID- 25943194 | In the first 24 hours, the patient presented with hypoglycemia attributed to hyperinsulinism and was treated with diazoxide. |
| PubMedID- 24621811 | In comparison with the severe hypoglycemia characteristic of patients with congenital hyperinsulinism (chi) secondary to loss of katp channel function (reviewed in [17]), sur1−/− mice, with the equivalent channel deficit, show near normal glucose homeostasis unless stressed [16], [18], [19], [20]. |
| PubMedID- 26392140 | Diazoxide is used to treat severe hypoglycemia due to hyperinsulinism of infancy. |
| PubMedID- 24639276 | The hypoglycemia was attributable to hyperinsulinism and was treated with diazoxide and chlorothiazide. |
| PubMedID- 23275527 | Context: hypoglycemia due to congenital hyperinsulinism (hi) is caused by mutations in 9 genes. |
| PubMedID- 23274908 | Deletion of foxa2 in all β-cells caused severe neonatal hypoglycemia with relative hyperinsulinism (45) that was at least partly attributable to defects in katp channels (46). |
| PubMedID- 25870695 | A high level of glucose should trigger more attention as rebound hyperinsulinism could appear with subsequent severe hypoglycemia [4]. |
| PubMedID- 26180531 | Congenital hyperinsulinism (chi) leads to hypoglycemia in infants and children due to inappropriately elevated insulin levels. |
| PubMedID- 26316438 | Unlike other congenital fatty acid oxidation defects, short-chain l-3-hydroxyacyl-coa (schad, hadh) deficiency is characterised by hypoglycemia with hyperinsulinism in the neonatal or infancy periods. |
| PubMedID- 22759688 | This case illustrates the complex relationship between seizures and hypoglycemia in hyperinsulinism-hyperammonemia syndrome that can create diagnostic difficulties. |
| PubMedID- 24275620 | But hypoglycemia due to hyperinsulinism, especially genetic causes, continued to be associated with brain injury. |
| PubMedID- 25618267 | Stress-related hyperinsulinism (hi) may lead to recalcitrant hypoglycemia for weeks or months following perinatal stress, often in premature newborn infants. |
| PubMedID- 22584561 | In this review, the authors studied 24 patients with hypoglycemia due to endogenous hyperinsulinism in order to describe aspects of diagnosis and treatment. |
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