PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | C0028754|obesity |
| Sentences | 40 |
| PubMedID- 22911568 | These effects of osa(r) are consistent with its potential use as a therapy for the hyperglycemia associated with obesity-related t2dm. |
| PubMedID- 24711854 | Chinese obese patients (defined as bmi > 28 kg/m2) with zheng “pi-wei-re” or “pi-qixu” were shown to have increased bmi compared to other patients; one study in 874 chinese subjects showed that zheng essential “re” (interior heat) and “yinxu” (yin deficiency) were closely related hyperglycemia associated with obesity; another study showed that subjects with zheng essential “tanshi” (phlegm-dampness obstruction) had increased waist circumference and waist-hip ratio (as measures for abdominal obesity) by comparison to non-“tanshi” subjects [20–22]. |
| PubMedID- 23853755 | The development of hyperglycemia is not associated with either obesity or insulitis but is associated with pancreatic β-cell dysfunction (wang et al. |
| PubMedID- 25821591 | The db/db mouse (bks/db−/−) is a typical model of type 2 diabetes that exhibits hyperglycemia associated with obesity a few 4–8 weeks after birth [20]. |
| PubMedID- 24371523 | Ms and its co-morbidities hyperglycemia, abdominal obesity, and hypertriglyceridemia were found to be higher in hypertensives compared to the general population [6]. |
| PubMedID- 25589832 | In addition, obesity is associated with hypertension and hyperglycemia, which might promote atherosclerosis [15,16]. |
| PubMedID- 20664725 | Diabetes mellitus, a metabolic disease characterized by hyperglycemia and often associated with obesity, is one of the leading causes of death in most developed countries [1]. |
| PubMedID- 21318112 | The strain is characterised by a high susceptibility to diet-induced obesity, with a moderate hyperglycemia and hyperinsulinemia [13, 14]. |
| PubMedID- 21235803 | obesity associated with hyperglycemia is a key factor that contributes to the development of diabetes-related microvascular disease both cyclooxygenase1 and cyclooxygenase2 and play a key role in the regulation of cardiovascular function, this increment resulted in rise of oxidative stress and reduction in no generation in microvessels endothelial cells [46], suggesting that no deficiency may contribute to renal vascular congestion and the renal dysfunction progression. |
| PubMedID- 25825681 | This model exhibits morbid obesity associated with hyperphagia and hyperglycemia along with other neuroendocrine abnormalities (coleman & hummel, 1973; coleman, 1982). |
| PubMedID- 25452853 | The association of obesity with hyperglycemia is well established29; obesity is one of the strongest and most important risk factors for type 2 diabetes.30 previous studies have demonstrated strong, positive associations of bmi with fasting glucose and hba1c with both prediabetes and diabetes,3132 consistent with our results. |
| PubMedID- 26184280 | Collectively, these results can provide a model to develop new agents for the treatment of hyperglycemia associated with obesity, and type 1 or type 2 diabetes [25]. |
| PubMedID- 25747866 | Hfd can induce obesity, which associated with hyperglycemia, hyperlipemia and impaired insulin sensitivity. |
| PubMedID- 23316315 | Db/db mice exhibit hyperglycemia, hyperinsulinemia, obesity, and dislipidemia and have thus been widely used as an experimental model of type 2 diabetes mellitus.11,19 however, these mice are functionally leptin deficient, a feature that could affect studies of postischemic neovascularization insofar as leptin is a proangiogenic factor.20 we thus sought to confirm that observations made in db/db mice were consequent to their diabetic phenotype and not secondary to functional leptin deficiency or obesity. |
| PubMedID- 21767357 | hyperglycemia, abdominal obesity, decreased hdl-cholesterol levels and hypertension, were measured twice in 6 years. |
| PubMedID- 22581287 | In both dietary and genetic obesity, liver-specific inhibition of nik markedly improved hyperglycemia and glucose intolerance. |
| PubMedID- 24843590 | hyperglycemia and lipotoxicity associated with obesity or insulin resistance are thought to be the main causes of cardiac cell death and ventricular dysfunction in diabetes. |
| PubMedID- 23599907 | Impaired glut4 membrane translocation is the primary cause of hyperglycemia, associated with obesity and type ii diabetes. |
| PubMedID- 24956416 | Resveratrol prevented the higher body weight, hyperphagia, visceral obesity, hyperleptinemia, hyperglycemia, insulin resistance, and hypoadiponectinemia at adulthood in animals that were early weaned. |
| PubMedID- 20425069 | These facts generally have been attributed to a high burden of risk factors such as hypertension, obesity, smoking, hyperglycemia, and dyslipidemia, many of which are associated with insulin resistance, resulting in a high cardiovascular risk phenotype among individuals with dm [3]. |
| PubMedID- 20498760 | The db/db mice are reported to develop significant obesity within 6 weeks of age showing hyperglycemia and hyperinsulinemia at fasting [11]. |
| PubMedID- 25810781 | On the other hand, oxidative dna damage detected in women with mild gestational hyperglycemia might be associated with repercussions from obesity, hypertension and/or insulin resistance. |
| PubMedID- 21274264 | Male tsod mice exhibit polygenic obesity with hyperglycemia and hyperinsulinemia [26, 27]. |
| PubMedID- 20671929 | Several potential mechanisms seem to link obesity with ad: hyperglycemia, advanced glycosylation products, adipokine action, and the influence of obesity on vascular risk and cerebrovascular disease. |
| PubMedID- 26197341 | Exaggerated fat intake and obesity lead to hyperglycemia, hyperlipidemia, and the over expressions of adipocytokines and chemokines and further contribute to insulin resistance in adipose tissue and the liver. |
| PubMedID- 25897330 | In this work, obesity was associated with hyperglycemia, insulin resistance and dyslipidemia. |
| PubMedID- 23758787 | Thus, hepatic cell traf2 autonomously promotes hepatic gluconeogenesis, and contributes to hyperglycemia in obesity [268]. |
| PubMedID- 21119886 | Among other factors, obesity along with chronic hyperglycemia may be implicated in the early sensorineural hearing loss [111]. |
| PubMedID- 22570665 | Maternal hyperglycemia is associated with obesity in the next generation [4, 5]. |
| PubMedID- 21447652 | Hepatic insulin resistance is defined as the inability of systemic hyperinsulinemia to suppress hgp and contributes to both fasting and postprandial hyperglycemia seen in patients with obesity and type 2 diabetes (7). |
| PubMedID- 22124716 | The age-dependent declines in the associations of obesity with hyperglycemia and dyslipidemia may partly explain the weaker association between obesity and the risk for coronary heart disease in older men than in younger men (8,9). |
| PubMedID- 24760503 | In chronic hfd‐feeding, once diet‐induced obesity with concomitant fasting hyperglycemia, hypertension, and tachycardia has set in, sbpv is significantly suppressed. |
| PubMedID- 24222736 | It is well known that central obesity together with hyperglycemia is a powerful risk factor in women, which may attenuate the usual protection cad women have [27]. |
| PubMedID- 25801507 | Therefore, although no one diet produced a phenotype that perfectly modeled the human condition, all three hfds resulted in characteristics that mirrored important features of type 2 diabetes, most notably including hyperglycemia associated with obesity and insulin resistance. |
| PubMedID- 21569551 | obesity associated with hyperglycemia is a key factor that contributes to the development of diabetes-related microvascular disease, cyclooxygenase which lead to increased oxidative stress and reduction in generation of nitric oxide in microvessels endothelial cells [50]. |
| PubMedID- 24410812 | Treatment of animals with recombinant adiponectin with obesity leads to decreased hyperglycemia and free fatty acids (ffa) in plasma and improves insulin sensitivity [35]. |
| PubMedID- 26092862 | Objective: obesity in the offspring of women with hyperglycemia during pregnancy has been reported, but the results are conflicting. |
| PubMedID- 25953257 | These results demonstrate that dietary obesity without hyperglycemia or hypertension attenuates the impact of ischemia/reperfusion injury in association with increased insulin signaling and risk activation. |
| PubMedID- 20393148 | In leptin receptor–deficient (db mutation) mouse strains, obesity is variably associated with hyperglycemia depending on genetic background (30). |
| PubMedID- 21211341 | Tnf-alpha expression in normal, simple obesity, obesity with hyperglycemia, obesity with hyperlipidemia, obesity with three metabolic disorders group at 48 h were (222 +/- 32), (246 +/- 52), (322 +/- 32), (322 +/- 34) and(490 +/- 83)ng/l, respectively, il-1beta (ng/l) were (94 +/- 19), (133 +/- 19), (174 +/- 22), (180 +/- 30), (279 +/- 38) (p < 0.05). |
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