PedAM
Pediatric Disease Annotations & Medicines
| Disease | hyperglycemia |
| Phenotype | C0020459|hyperinsulinemia |
| Sentences | 32 |
| PubMedID- 26253538 | hyperglycemia, in association with hyperinsulinemia, stimulates this metabolic change but may have deleterious effects on left ventricular (lv) function. |
| PubMedID- 24267821 | Although the compensatory hyperinsulinemia prevents development of fasting hyperglycemia in insulin-resistant individuals, the increased level of circulating insulin directly and/or indirectly affects different molecular signaling and can promote prostatic growth. |
| PubMedID- 22262970 | In type 2 diabetes, hyperglycemia is often associated with hyperinsulinemia (depending on the stage of diabetes), dyslipidemia, arterial hypertension, and other metabolic abnormalities that may modify the impact of acute hyperglycemia on vascular function [19, 20]. |
| PubMedID- 26073222 | Llamas showed that hyperglycemia coexisted with hyperinsulinemia (in general on the hp diet; postprandially on the lp diet). |
| PubMedID- 22454628 | Since hyperglycemia is associated with hyperinsulinemia, coinciding with the onset of laminin accumulation in the kidney in db/db mice, augmented laminin mrna translation could be due to either elevated glucose or high insulin. |
| PubMedID- 23805905 | It has been reported that akt2-null mice develop insulin resistance and mild hyperglycemia with hyperinsulinemia [40] as akt2 is a key protein involved in signal transduction. |
| PubMedID- 21593291 | Borderline hyperglycemia was associated with hyperfiltration, whereas hyperinsulinemia was not. |
| PubMedID- 25961053 | hyperglycemia with hyperinsulinemia and dyslipidemia are apparent as early as 8 weeks of age, before the animal reaches maturity, and are sustained throughout life [25, 26]. |
| PubMedID- 20427685 | By 1961, pedersen (1) had already described the phenotype of the infant with prenatal exposure to maternal diabetes as “most conspicuous…, the round cherub's cheeks, buried eyes, and short neck.” he suggested that maternal hyperglycemia leads to fetal hyperinsulinemia and increased growth, a hypothesis that is still the basis of research on maternal-fetal metabolism. |
| PubMedID- 22174765 | The cellular basis for either prion-induced cachexia or obesity is not completely understood, but an analysis of energy homeostasis in 139h scrapie in sgh revealed a preclinical hyperphagia, non-fasted hyperinsulinemia with hyperglycemia, and fasted hyperleptinemia that is consistent with an anabolic syndrome that had similarities to type ii diabetes mellitus [31], [32]. |
| PubMedID- 21033077 | In 60,3% of the carriers w/w genotype of adrb3 gene revealed a combination of hyperglycemia with hyperinsulinemia and/or tg. |
| PubMedID- 25893200 | In contrast to stz diabetes, nutritionally induced diabetes in po is characterized by innate insulin resistance, beta-cell dysfunction [21], hyperinsulinemia [22], gradual development of mild hyperglycemia, overweight, and upregulated pancreatic and circulated glp-1 secretion [23]. |
| PubMedID- 26166726 | hyperglycemia with and without hyperinsulinemia decreased bdnf mrna levels in the pituitary. |
| PubMedID- 25784953 | The male mkr mice exhibit hyperinsulinemia by 2–3 weeks of age, and hyperglycemia by 5–6 weeks of age with decreased whole body glucose uptake, failure to suppress hepatic gluconeogenesis in response to insulin and pancreatic beta cell dysfunction [13,14]. |
| PubMedID- 25354845 | Glucose transport across the placenta is driven by the maternal:fetal glucose ratio and thus maternal hyperglycemia can lead to fetal hyperglycemia, hyperinsulinemia, enhanced glycogen synthesis, and lipogenesis.40 glucose is the principal substrate supplying the uterus, placenta, and fetus41 and is an essential component in fetal growth, with concentrations increasing as gestation progresses.40 these data demonstrate that throughout pregnancy, f1 females born to ob mothers exhibit marked increases in insulin resistance when compared to f1 females born to con mothers independent of a difference in maternal diet, potentially subjecting their fetuses to the same blood glucose elevations as their mothers during fetal life. |
| PubMedID- 24278193 | Finally, ob mice on the fvb/n background have persistent hyperinsulinemia with hyperglycemia but without any signs of premature β-cell failure [46]. |
| PubMedID- 23573121 | Therefore, hyperglycemia coupled with hyperinsulinemia develops over time [22], a process which is intimately involved in the pathophysiological process of diabetic cardiomyocyte hypertrophy [23, 24]. |
| PubMedID- 23248408 | Type 2 diabetes mellitus is a progressive metabolic disease characterized by impaired glucose tolerance and postprandial hyperglycemia associated with insulin resistance, hyperinsulinemia, and impaired insulin secretion. |
| PubMedID- 26015434 | hyperinsulinemia prevents the actions of moderate hyperglycemia to reduce endothelial function and increase proinflammatory and proatherothrombotic markers. |
| PubMedID- 20713684 | Further, insulin resistance (hyperinsulinemia without hyperglycemia) is stronger in people with pre-diabetes than those with frank diabetes (42). |
| PubMedID- 23700465 | As a result, hyperleptinemia is followed by hyperinsulinemia, which leads to hyperglycemia in the long term [28]. |
| PubMedID- 23844375 | Mice in the c57blks/j stain exhibit hyperinsulinemia at 10 days of age and slight hyperglycemia at 1 month of age. |
| PubMedID- 24089612 | Db/db mouse model is characterized by early hyperinsulinemia with marked hyperglycemia progressing with age to slowly developing islet failure. |
| PubMedID- 21253478 | Maternal hyperglycemia leading to fetal hyperinsulinemia has been suggested to be responsible for some of this increase in risk [12]. |
| PubMedID- 25736710 | Since sdt fattyrats develop marked hyperglycemia with hyperinsulinemia, hyperlipidemia and hypertensionshortly after weaning [12,13,14, 17, 19, 23], sdt fatty rats develop severe microvascular complications at anearly age [17, 19, 20]. |
| PubMedID- 23691518 | This combination induced mild hyperglycemia and hypertriglyceridemia associated with mild fasting hyperinsulinemia and whole body insulin resistance, without significant increase in body weight [76]. |
| PubMedID- 26237598 | Postprandial hyperglycemia ensues, with compensatory hyperinsulinemia, resultant hyperlipidemia and elevated free radical stress. |
| PubMedID- 23874146 | Increased insulin resistance causes hyperglycemia leading to hyperinsulinemia and it amplifies lh action on theca cells and again increase in androgen level [10, 13]. |
| PubMedID- 20553919 | Although, the compensatory hyperinsulinemia prevents development of fasting hyperglycemia in insulin-resistant individuals, the increased level of circulating insulin directly and/or indirectly affects different molecular signaling and can promote prostatic growth. |
| PubMedID- 20700413 | In the present study, the control group of rats on a middle-carbohydrate/middle-fat diet exhibits the same spectrum of abnormalities, that is, high body weight, hypertension, hyperglycemia with hyperinsulinemia, elevated lipids and tgf-beta expression together with proteinuria, glomerular and interstitial fibrosis with evidence of intrarenal advanced glycation and oxidative stress. |
| PubMedID- 25302192 | hyperglycemia along with hyperinsulinemia, hypercholesterolemia and hypertriglyceridemia was observed in individuals having impaired fasting glucose. |
| PubMedID- 22654584 | A few minutes after the ingestion of carbohydrate-rich food a marked hyperglycemia leading to hyperinsulinemia is observed [33, 34] which are both highly undesirable in patients suffering from niddm, obesity or hyperlipoproteinemia. |
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