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PedAM

Pediatric Disease Annotations & Medicines




Disease hyperglycemia
Phenotype C0011860|type ii diabetes
Sentences 5
PubMedID- 23599907 Impaired glut4 membrane translocation is the primary cause of hyperglycemia, associated with obesity and type ii diabetes.
PubMedID- 24315942 Deficiency in the number of insulin-producing beta cells - a primary cause of type i diabetes and a secondary contributor of type ii diabetes - leads to hyperglycemia and hence an increase in the need for insulin.
PubMedID- 24137241 This rat model successfully imitated human type ii diabetes, with moderate hyperglycemia, hypertension, dyslipidemia and insulin resistance.
PubMedID- 26041445 Thus, hyperglycemia in type ii diabetes leads to renal dysfunction at least in part by inducing accumulation of hexcers and laccers in mesangial cells, resulting in fibrosis, extracellular matrix production, and hypertrophy.
PubMedID- 21701685 Suppressed pancreatic β cell insulin production [5] and impaired glucose uptake in skeletal muscle [6], [7], are major contributors to hyperglycemia, which eventually leads to type ii diabetes.

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